The Effect of sage and borage plants and their composition on nonalcoholic fatty liver of rats

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Rezaei Saber Amir Parviz; Taghilou Hossein; Aftabi Saeed; Karimi Johani Reza

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Journal: Research in Medicine Year:2022 | Volume:46 | Issue:2 Page(s): 57-67

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Information Journal Paper

Title

The Effect of sage and borage plants and their composition on nonalcoholic fatty liver of rats

Author(s)

Rezaei Saber Amir Parviz | Taghilou Hossein | Aftabi Saeed | Karimi Johani Reza | Issue Writer Certificate

Keywords

Silybum marianum

Eryngium

non

alcoholic liver

Abstract

Background and Aim: non-alcoholic fatty liver disease is a condition in which triglycerides accumulate in liver cells of individuals who do not have a history of alcohol use or use alcohol at a low rate. The aim of the current study was to investigate the effect of alcoholic extracts of St. John's wort and borage plants individually and in combination on nonalcoholic fatty liver in Wistar rats. These two plants were selected due to their innovation and high antioxidant characteristics. Methods: In the present experimental laboratory intervention study, 70 male Wistar rats were randomly divided into 7 groups of 10, and 10 mice were randomly assigned as the negative control group and the rest were treated with a high-fat diet. Next, 21 days after the onset of a high fat diet and fatty liver, they began to be treated with an alcoholic extract of Silybum marianum and Eryngium and kept for 2 months individually and combined in two doses of at least 200 and a maximum of 400 mg in kg. At the end of the treatment period in 1398 and to evaluate the level of concentrations of unsaturated fatty acids (NEFA), non-esterified fatty acids (BHB: hydroxybutyrate-Beta), alanine aminotransferase (ALT), aspartate amino trans (AST) Aspartate aminotransferase, and gamma glutamyl transferase (GGT) blood samples were taken and the data were analyzed. The findings were analyzed using SPSS, version 24. The results were compared using one-way analysis of variance statistical test at 95% probability level and the significance level of 0. 05. Results: The results showed that NEFA, BHBA, ALT, AST, and GGT levels in the treated groups of alcoholic extract of Silybum marianum and Eryngium combination and single effect on fatty liver were more than those in the control group and positive control group (P <0. 05). The amounts of AST in the control and positive, the negative, and combined control groups were 145. 4 ±,9. 1, 114 ±,11. 4, and 136. 1 ±,2. 9, respectively. Conclusion: It seems that thistle and buckthorn can be used to treat non-alcoholic fatty liver disease, which of course requires clinical trials in livestock, which improves the amount of liver enzymes due to the effect of these plants on liver tissue and improving the amount of related enzymes. Therefore, these plants can be used in future research on livestock and their effects on improving liver enzymes and protecting liver tissue.

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References

Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L. ) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats

Cite

APA: Copy

Rezaei Saber, Amir Parviz, Taghilou, Hossein, Aftabi, Saeed, & Karimi Johani, Reza. (2022). The Effect of sage and borage plants and their composition on nonalcoholic fatty liver of rats. PAJOUHESH DAR PEZESHKI, 46(2 ), 57-67. SID. https://sid.ir/paper/1009246/en

Vancouver: Copy

Rezaei Saber Amir Parviz, Taghilou Hossein, Aftabi Saeed, Karimi Johani Reza. The Effect of sage and borage plants and their composition on nonalcoholic fatty liver of rats. PAJOUHESH DAR PEZESHKI[Internet]. 2022;46(2 ):57-67. Available from: https://sid.ir/paper/1009246/en

IEEE: Copy

Amir Parviz Rezaei Saber, Hossein Taghilou, Saeed Aftabi, and Reza Karimi Johani, “The Effect of sage and borage plants and their composition on nonalcoholic fatty liver of rats,” PAJOUHESH DAR PEZESHKI, vol. 46, no. 2 , pp. 57–67, 2022, [Online]. Available: https://sid.ir/paper/1009246/en

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