The effect of aloe vera extract and synthesized green nanoparticles on reducing inflammation in psoriasis: an in vitro study

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NEMATI HOUSHANG; KHAZAEI MOZAFAR; Nazeri Mehri; Bozorgi Maryam

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Journal Paper

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Journal: Dermatology and Cosmetics Year:2022 | Volume:13 | Issue:1 Page(s): 29-39

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Title

The effect of aloe vera extract and synthesized green nanoparticles on reducing inflammation in psoriasis: an in vitro study

Author(s)

NEMATI HOUSHANG | KHAZAEI MOZAFAR | Nazeri Mehri | Bozorgi Maryam | Issue Writer Certificate

Keywords

psoriasis

aloe vera

nanoparticles

gene expression

Abstract

Background and Aim: psoriasis is a chronic inflammatory skin disease, influenced by genetic and immune-based factors that is associated with skin inflammation. aloe vera gel is traditionally used to treat skin diseases including psoriasis. Methods: In this study, ethanolic extract of aloe vera gel was evaluated for its anti-inflammatory and antioxidant activity in skin-derived A431 cells. First, after preparing the extract and then the green synthesis of gold nanoparticles using the extract, their effect on the expression of inflammatory genes as well as their antioxidant properties were investigated. Results: The use of different concentrations of aloe vera extract caused a relative increase in EGFR and Nrf2 expression levels and decreased expression of NF-κ, B, TNF-α,and IL-6 inflammatory genes in A431 skin cells. But the effect of synthesized nanoparticles was greater than aloe vera extract in altering the expression of signaling and inflammatory genes. Conclusion: The synthesized extracts and nanoparticles had antioxidant properties and also reduced the expression of inflammatory genes in cells. However, the effect of nanoparticles was much greater than that of extracts in reducing inflammatory genes.

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APA: Copy

NEMATI, HOUSHANG, KHAZAEI, MOZAFAR, Nazeri, Mehri, & Bozorgi, Maryam. (2022). The effect of aloe vera extract and synthesized green nanoparticles on reducing inflammation in psoriasis: an in vitro study. DERMATOLOGY AND COSMETIC, 13(1 ), 29-39. SID. https://sid.ir/paper/1014708/en

Vancouver: Copy

NEMATI HOUSHANG, KHAZAEI MOZAFAR, Nazeri Mehri, Bozorgi Maryam. The effect of aloe vera extract and synthesized green nanoparticles on reducing inflammation in psoriasis: an in vitro study. DERMATOLOGY AND COSMETIC[Internet]. 2022;13(1 ):29-39. Available from: https://sid.ir/paper/1014708/en

IEEE: Copy

HOUSHANG NEMATI, MOZAFAR KHAZAEI, Mehri Nazeri, and Maryam Bozorgi, “The effect of aloe vera extract and synthesized green nanoparticles on reducing inflammation in psoriasis: an in vitro study,” DERMATOLOGY AND COSMETIC, vol. 13, no. 1 , pp. 29–39, 2022, [Online]. Available: https://sid.ir/paper/1014708/en

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