Synthesis and optimization of effective dose of niosomal amikacin for antibacterial activity on Pseudomonas aeruginosa

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Rahimi Fardin; Bahramgour Mahsa; AMOABEDINY GHASSEM; Bagheri Pebdeni Azam; Ebrahimi hosseinzadeh Bahman; Amoabediny Zeynab

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2021 | Volume:29 | Issue:157 Page(s): 86-100

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Title

Synthesis and optimization of effective dose of niosomal amikacin for antibacterial activity on Pseudomonas aeruginosa

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Keywords

Nanosystem

Niosome

Amikacin

Antibacterial activity

Pseudomonas aeruginosa

Abstract

Background and Objective: Niosomes are one of the new drug delivery systems. In this synthesis study, the properties and characteristics of Nanosystems loaded Amikacin for the aim of slow releasing and Antibacterial activity on Pseudomonas aeruginosa were been investigated. Materials and Methods: The synthesis nanocarriers were characterized by using DLS, zeta potential, SEM images, and FTIR analysis. The percentage of drug loading in the Nanosystems were measured. After that, the release rate of the drug was checked. MIC microbiological tests were performed to determine the minimum inhibitory concentration (MIC) of Pseudomonas aeruginosa. Finally, with MTT method, the toxicity and effectiveness of the system on cell line A549 extracted from lung were evaluated. Results: In this study, by synthesis and optimization, with the highest loading efficiency of 95. 15% at the formulations and the slowest release with a drug release rate of 65. 27% in 60 hours to reduce the side effects of Amikacin. We were able to increase the antimicrobial activity of Amikacin niosomal against Pseudomonas aeruginosa and reduce the side effects compared to the free form and have a slower and more continuous release with greater effectiveness on bacteria. Studying this process on the lung cell lines was successful and free-form of Amikacin has a more toxic effect than two drug-free and drug-free niosomal systems. Numerous mathematical models, including realistic and experimental/quasi-experimental mechanistic models, have been successfully introduced to quantitatively define drug release mechanisms and play an important role in designing a drug delivery system for drug release diagrams. That reported in results Conclusion: Achieving optimal conditions for the preparation of Nanosystems carrying Amikacin and investigating the effect of this system on bacterial agents is an important step in science, research, and economic efficiency.

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APA: Copy

Rahimi, Fardin, Bahramgour, Mahsa, AMOABEDINY, GHASSEM, Bagheri Pebdeni, Azam, Ebrahimi hosseinzadeh, Bahman, & Amoabediny, Zeynab. (2022). Synthesis and optimization of effective dose of niosomal amikacin for antibacterial activity on Pseudomonas aeruginosa. DANESHVAR MEDICINE, 29(157 ), 86-100. SID. https://sid.ir/paper/1015181/en

Vancouver: Copy

Rahimi Fardin, Bahramgour Mahsa, AMOABEDINY GHASSEM, Bagheri Pebdeni Azam, Ebrahimi hosseinzadeh Bahman, Amoabediny Zeynab. Synthesis and optimization of effective dose of niosomal amikacin for antibacterial activity on Pseudomonas aeruginosa. DANESHVAR MEDICINE[Internet]. 2022;29(157 ):86-100. Available from: https://sid.ir/paper/1015181/en

IEEE: Copy

Fardin Rahimi, Mahsa Bahramgour, GHASSEM AMOABEDINY, Azam Bagheri Pebdeni, Bahman Ebrahimi hosseinzadeh, and Zeynab Amoabediny, “Synthesis and optimization of effective dose of niosomal amikacin for antibacterial activity on Pseudomonas aeruginosa,” DANESHVAR MEDICINE, vol. 29, no. 157 , pp. 86–100, 2022, [Online]. Available: https://sid.ir/paper/1015181/en

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