Efficacy of Beta D-Glucan Serologic Test in Invasive Fungal Infections Early Detection in Patients with Hematologic Malignancies in Southern Iran

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ZAHEDI E.; Dehghanian a.; REZVANI A.; BARZEGAR A.

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Journal: Sadra Medical Sciences Journal Year:2021 | Volume:9 | Issue:4 Page(s): 343-352

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Title

Efficacy of Beta D-Glucan Serologic Test in Invasive Fungal Infections Early Detection in Patients with Hematologic Malignancies in Southern Iran

Author(s)

ZAHEDI E. | Dehghanian a. | REZVANI A. | BARZEGAR A. | Issue Writer Certificate

Keywords

Hematologic Neoplasms

Invasive Fungal Infections

Beta-D-Glucan

Abstract

Introduction: Fungal infections are a major concern in immunocompromised patients, such as patients with hematologic malignancies and bone marrow transplants. Opportunistic infections such as Invasive Fungal Infections can lead to poor outcomes and a high probability of death in such patients. Gold standard methods of fungi detection are intrusive and time-consuming. Therefore, they may not be the method of choice to detect such infections rapidly,however, they are always mandatory. Next to gold-standard methods, serologic methods are rapid and non-invasive methods that have been approved for use as an adjunct to classic methods for quicker detection of fungal infections. Methods: In this study, 68 patients diagnosed with hematologic malignancies and suspicious of fungal infection were enrolled to detect fungi with serologic testing of Beta D-Glucan using ELISA. The authors evaluated the association of malignancy type, clinical signs, and patients’,para-clinical data with positive Beta D-Glucan tests. Results: Out of 43 men and 25 women participating in this study, 79% had positive test results. Conclusion: There was no significant association between malignancy type, clinical signs, patients’,para-clinical data, and their positive serology tests. Considering the probable false-positive results due to infection and the use of certain antibiotics in such immunocompromised patients, the authors concluded that the Beta D-Glucan ELISA test might not be a sensitive diagnosis means to diagnose fungal infections in patients with hematologic malignancies.

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APA: Copy

ZAHEDI, E., Dehghanian, a., REZVANI, A., & BARZEGAR, A.. (2021). Efficacy of Beta D-Glucan Serologic Test in Invasive Fungal Infections Early Detection in Patients with Hematologic Malignancies in Southern Iran. SADRA MEDICAL SCIENCES JOURNAL, 9(4 ), 343-352. SID. https://sid.ir/paper/1015558/en

Vancouver: Copy

ZAHEDI E., Dehghanian a., REZVANI A., BARZEGAR A.. Efficacy of Beta D-Glucan Serologic Test in Invasive Fungal Infections Early Detection in Patients with Hematologic Malignancies in Southern Iran. SADRA MEDICAL SCIENCES JOURNAL[Internet]. 2021;9(4 ):343-352. Available from: https://sid.ir/paper/1015558/en

IEEE: Copy

E. ZAHEDI, a. Dehghanian, A. REZVANI, and A. BARZEGAR, “Efficacy of Beta D-Glucan Serologic Test in Invasive Fungal Infections Early Detection in Patients with Hematologic Malignancies in Southern Iran,” SADRA MEDICAL SCIENCES JOURNAL, vol. 9, no. 4 , pp. 343–352, 2021, [Online]. Available: https://sid.ir/paper/1015558/en

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