Effect of Glucose Whole-cell Patch-clamp on Cardiac Sodium Channel Current

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KHAZRAEI H.; Ostovan v.r.

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Journal Paper

Paper Information

Journal: Sadra Medical Sciences Journal Year:2021 | Volume:9 | Issue:4 Page(s): 333-342

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Title

Effect of Glucose Whole-cell Patch-clamp on Cardiac Sodium Channel Current

Author(s)

KHAZRAEI H. | Ostovan v.r. | Issue Writer Certificate

Keywords

Glucose

Patch-clamp

Sodium channel

Abstract

Introduction: Cardiac Na+ channels are responsible for the excitation of the cardiac cells. Hyperglycemia is the chief symptom of diabetes and several other complications. Although many studies have been conducted on diabetic cardiomyopathy, the role of high Glucose on sodium current has not been completely clarified. In the present study, the authors investigated the role of high Glucose concentration on human cardiac Sodium channels current in transfected HEK293 cells. Methods: The authors evaluated Glucose effects on sodium current using the whole-cell Patch-clamp technique. Results: The data indicated that Na+ current was significantly modified with an overnight exposure to high Glucose. For steady-state activation, high Glucose-induced insignificant hyperpolarizing shifted the V1/2. Steady-state inactivation shifted to more negative potentials with Glucose exposure (p<0. 001). Conclusions: Data suggested that the Glucose effect on two forms of Sodium channel gates (activation and inactivation) raises the possibility of metabolic modulations of Sodium channel activity. A hyperpolarized shift of activation and inactivation is supposed to enhance cardiac cell excitability.

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References

Mechanical effects of ranolazine on normal and diabetic-isolated rat heart

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APA: Copy

KHAZRAEI, H., & Ostovan, v.r.. (2021). Effect of Glucose Whole-cell Patch-clamp on Cardiac Sodium Channel Current. SADRA MEDICAL SCIENCES JOURNAL, 9(4 ), 333-342. SID. https://sid.ir/paper/1015583/en

Vancouver: Copy

KHAZRAEI H., Ostovan v.r.. Effect of Glucose Whole-cell Patch-clamp on Cardiac Sodium Channel Current. SADRA MEDICAL SCIENCES JOURNAL[Internet]. 2021;9(4 ):333-342. Available from: https://sid.ir/paper/1015583/en

IEEE: Copy

H. KHAZRAEI, and v.r. Ostovan, “Effect of Glucose Whole-cell Patch-clamp on Cardiac Sodium Channel Current,” SADRA MEDICAL SCIENCES JOURNAL, vol. 9, no. 4 , pp. 333–342, 2021, [Online]. Available: https://sid.ir/paper/1015583/en

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