Comparison of Pro-inflammatory Gene Expression Profile in Spleen and Peripheral Blood Neutrophils of BALB/C Mice Infected with Leishmania Major

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZVAN HOSSEIN; HAMOONNAVARD SAHAR; AKHZARI SOHEYLA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2022 | Volume:29 | Issue:11 Page(s): 4268-4280

Download Full-Text

Persian Verion

View:

107

Download:

Cites:

Information Journal Paper

Title

Comparison of Pro-inflammatory Gene Expression Profile in Spleen and Peripheral Blood Neutrophils of BALB/C Mice Infected with Leishmania Major

Author(s)

REZVAN HOSSEIN | HAMOONNAVARD SAHAR | AKHZARI SOHEYLA | Issue Writer Certificate

Keywords

Leishmania

Neutrophil

Spleen

Pro-inflammatory

Genes

Abstract

Introduction: Leishmaniasis is one of the common diseases between humans and animals. The present study was to investigate the expression pattern of Pro-inflammatory Genes in different stages of cutaneous Leishmaniasis progression in order to provide a standard framework for diagnosis of various stages of the disease. Methods: In this experimental study, 2×10 6 Leishmania major were injected in two groups of BALB/c mice in the base of the tail. After skin lesion, the animals were divided into control group, without treatment and the test group treated with glucantime for 30 days by intralesion injection. At the end of the second and fourth weeks of treatment, gene expression cytokines IL-12p35, CCL3, CCL4, IL-12p40, TNF-α, , CCL5, IL1α, , IL-1β, , IFN-γ,and CCR5 was performed in peripheral blood Neutrophil cells and Spleen cells using conventional PCR technique. The data were analyzed through SPSS software version 16,t-tests, ANOVA and Tukey's test were also run (P ˂, 0. 05). Results: In Leishmania infected mice, before treatment with glucantime, IFN-γ, , IL-1β, , CCR5, CCL-5, IL12p40, IL-12p35 in peripheral blood Neutrophils and IFN-γ,in the Spleens were expressed, which was different from the expression pattern of the Genes in Leishmania infected mice treated with Glucantim. Conclusion: The cytokines (IFN-γ, , IL-12, TNF-α, ) are important factors affecting the immune response as reducing the expression of these Genes causes the lesion progression in Leishmaniasis.

Cites

No record.

References

Cite

APA: Copy

REZVAN, HOSSEIN, HAMOONNAVARD, SAHAR, & AKHZARI, SOHEYLA. (2022). Comparison of Pro-inflammatory Gene Expression Profile in Spleen and Peripheral Blood Neutrophils of BALB/C Mice Infected with Leishmania Major. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 29(11 ), 4268-4280. SID. https://sid.ir/paper/1016587/en

Vancouver: Copy

REZVAN HOSSEIN, HAMOONNAVARD SAHAR, AKHZARI SOHEYLA. Comparison of Pro-inflammatory Gene Expression Profile in Spleen and Peripheral Blood Neutrophils of BALB/C Mice Infected with Leishmania Major. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;29(11 ):4268-4280. Available from: https://sid.ir/paper/1016587/en

IEEE: Copy

HOSSEIN REZVAN, SAHAR HAMOONNAVARD, and SOHEYLA AKHZARI, “Comparison of Pro-inflammatory Gene Expression Profile in Spleen and Peripheral Blood Neutrophils of BALB/C Mice Infected with Leishmania Major,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 11 , pp. 4268–4280, 2022, [Online]. Available: https://sid.ir/paper/1016587/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops