Effect of spinach (Spinacia oleracea L. ) extract on chronic restraint stress-induced memory deficit and anxiety in male rats

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Tarasi Masoumeh; Asle Rousta Masoumeh

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:169 Page(s): 48-55

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Title

Effect of spinach (Spinacia oleracea L. ) extract on chronic restraint stress-induced memory deficit and anxiety in male rats

Author(s)

Tarasi Masoumeh | Asle Rousta Masoumeh | Issue Writer Certificate

Keywords

Spinach (Spinacia oleracea L.)Q1

Spatial memoryQ2

AnxietyQ2

Restraint stressQ2

RatQ2

Abstract

Background: Spinach (Spinacia oleracea L. ) has antioxidant, antiinflammatory, antiapoptotic and neuroprotective properties. The aim of this study was to investigate the effect of spinach hydroalcoholic extract on chronic Restraint stress-induced spatial learning and memory deficit and Anxiety in adult male Rats. Methods: 60 adult male Wistar Rats were allocated to six groups: Control group, Spinach200 and Spinach400 groups (were gavaged with hydroalcoholic extract of spinach at 200, 400 mg/ kg/bw doses), Stress group (restrained in restrainers for 6hours per day for 21 consecutive days), Stress-Spinach200 and Stress-Spinach400 groups (received spinach extract in addition to chronic immobility stress). Spatial learning and memory and Anxiety were examined through the Morris water maze (MWM) test and elevated plus maze (EPM) respectively. Results: Chronic immobilization stress caused spatial learning and memory impairment and Anxiety-like behavior. Escape latency and distance moved to reach the hidden platform had dramatic decrease in Stress-Spinach groups compare with Stress group (p<0. 01 and p<0. 05 respectively). Consuming both doses of spinach extract caused significant increase in spent time and swam distance in target quadrant by Stress-Spinach groups comparing with stress group (p<0. 01 and p<0. 05). Taking both doses of the extract led to significant increase in percentages of open arm entry and time spent in open arm in EPM test compared with Stress Group (p<0. 01 and p<0. 05 respectively). Conclusion: It has been concluded that due to rich antioxidant amount in spinach ethanol extract, it can improve spatial learning and memory and reduce Anxiety in Restraint stress exposed Rats.

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APA: Copy

Tarasi, Masoumeh, & Asle Rousta, Masoumeh. (2018). Effect of spinach (Spinacia oleracea L. ) extract on chronic restraint stress-induced memory deficit and anxiety in male rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(169 ), 48-55. SID. https://sid.ir/paper/10167/en

Vancouver: Copy

Tarasi Masoumeh, Asle Rousta Masoumeh. Effect of spinach (Spinacia oleracea L. ) extract on chronic restraint stress-induced memory deficit and anxiety in male rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(169 ):48-55. Available from: https://sid.ir/paper/10167/en

IEEE: Copy

Masoumeh Tarasi, and Masoumeh Asle Rousta, “Effect of spinach (Spinacia oleracea L. ) extract on chronic restraint stress-induced memory deficit and anxiety in male rats,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 169 , pp. 48–55, 2018, [Online]. Available: https://sid.ir/paper/10167/en

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