Effect of Training Intensity on HIF-1a Gene Expression and Cardiac TG Content in Rats with Non-Alcoholic Fatty Liver Disease

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Bagherian Mahdi; BANAEIFAR ABDOLALI; ARSHADI SAJAD; AZARBAYJANI MOHAMMAD ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2022 | Volume:30 | Issue:7 Page(s): 5062-5076

Download Full-Text

Persian Verion

View:

189

Download:

Cites:

Information Journal Paper

Title

Effect of Training Intensity on HIF-1a Gene Expression and Cardiac TG Content in Rats with Non-Alcoholic Fatty Liver Disease

Author(s)

Bagherian Mahdi | BANAEIFAR ABDOLALI | ARSHADI SAJAD | AZARBAYJANI MOHAMMAD ALI | Issue Writer Certificate

Keywords

Low intensity endurance Training

High intensity interval training

HIF-1a

Heart tissue

Triglyceride

Abstract

Introduction: HIF-1a is an important regulator in response to hypoxia that affects various genes involved in energy metabolism. The aim of this study was to investigate the effect of exercise intensity on HIF-1a gene expression and cardiac TG content in rats with non-alcoholic fatty liver disease. Methods: The present study was performed experimentally on 40 male Wistar rats. Mice were randomly divided into 4 groups. The control groups, low-intensity endurance training and intense interval training, consumed high-fat food for 16 weeks, and then the two training groups participated in exercise for 8 weeks. Furthermore, sham group, which used standard food during this period, at the end of training, the expression level of HIF-1a and the amount of intra-tissue fat of the heart were measured in 4 groups. HIF-1a expression was assessed using real-time PCR and TG assay on an autoanalyzer. SPSS software version 16 and analysis of variance were used to analyze the data. Results: The results showed that there was a significant difference in the expression of HIF-1a gene between the control and the sham groups, HIIT and LIET groups (P=0. 001). Moreover, there was a significant difference in Triglyceride between HIIT and LIET groups compared to the sham and control groups, but no significant difference was observed between HIIT and LIET groups (P=0. 0001). Conclusion: The results showed that intense intermittent exercise and low-intensity continuous exercise may reduce cardiac Triglyceride content by decreasing HIF-1a expression and increasing fatty acid oxidation.

Cites

No record.

References

Cite

APA: Copy

Bagherian, Mahdi, BANAEIFAR, ABDOLALI, ARSHADI, SAJAD, & AZARBAYJANI, MOHAMMAD ALI. (2022). Effect of Training Intensity on HIF-1a Gene Expression and Cardiac TG Content in Rats with Non-Alcoholic Fatty Liver Disease. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 30(7 ), 5062-5076. SID. https://sid.ir/paper/1017080/en

Vancouver: Copy

Bagherian Mahdi, BANAEIFAR ABDOLALI, ARSHADI SAJAD, AZARBAYJANI MOHAMMAD ALI. Effect of Training Intensity on HIF-1a Gene Expression and Cardiac TG Content in Rats with Non-Alcoholic Fatty Liver Disease. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;30(7 ):5062-5076. Available from: https://sid.ir/paper/1017080/en

IEEE: Copy

Mahdi Bagherian, ABDOLALI BANAEIFAR, SAJAD ARSHADI, and MOHAMMAD ALI AZARBAYJANI, “Effect of Training Intensity on HIF-1a Gene Expression and Cardiac TG Content in Rats with Non-Alcoholic Fatty Liver Disease,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 7 , pp. 5062–5076, 2022, [Online]. Available: https://sid.ir/paper/1017080/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops