The Mechanism of Treatment Failure in AML

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Noorazar L.; MEHDIZADEH M.; Farhadi Hosseinabadi B.; PARKHIDEH S.; HAJIFATHALI A.

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Journal Paper

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Journal: Yafteh Year:2021 | Volume:23 | Issue:1 (89) Page(s): 63-74

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Title

The Mechanism of Treatment Failure in AML

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Keywords

Acute myeloblastic leukemia

Treatment failure

Drug resistance

Abstract

Acute myeloid leukemia (AML) is hematologic cancer caused by abnormal stem cell differentiation, which lead to the gathering of abnormal cells in the bone marrow. Today, with discovery and application of new drug such as monoclonal antibodies, the toxicity of chemo-therapy has been decreased. These drugs are conjugated with mAbs that enable them to target the malihnancy cells more accurately. Despite advances in the design and use of various drugs for AML treatment, leukemic cells using various mechanisms can become resistant to the cytotoxicity of drugs. Indeed, these factors result in cancer survival and Treatment failure. On the other hand, predicting prognosis and relapse of the disease depends on Drug resistance of leukemic cells and choosing of treatment process. Our aim in this review article is to investigate the most common ways of AML Treatment failure. By knowing these factors, more effective drugs are produced and new therapeutic protocoles are used in the treatment of AML.

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APA: Copy

Noorazar, L., MEHDIZADEH, M., Farhadi Hosseinabadi, B., PARKHIDEH, S., & HAJIFATHALI, A.. (2021). The Mechanism of Treatment Failure in AML. YAFTEH, 23(1 (89) ), 63-74. SID. https://sid.ir/paper/1018543/en

Vancouver: Copy

Noorazar L., MEHDIZADEH M., Farhadi Hosseinabadi B., PARKHIDEH S., HAJIFATHALI A.. The Mechanism of Treatment Failure in AML. YAFTEH[Internet]. 2021;23(1 (89) ):63-74. Available from: https://sid.ir/paper/1018543/en

IEEE: Copy

L. Noorazar, M. MEHDIZADEH, B. Farhadi Hosseinabadi, S. PARKHIDEH, and A. HAJIFATHALI, “The Mechanism of Treatment Failure in AML,” YAFTEH, vol. 23, no. 1 (89) , pp. 63–74, 2021, [Online]. Available: https://sid.ir/paper/1018543/en

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