Sitagliptin Suppresses Apoptotic Cell Death and Histological Changes in the Ovaries of Rats with Polycystic Ovary Syndrome

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Safaeian Azadeh; Zare Mehrjerdi Fatemeh; YADEGARI MARYAM; REZVANI MOHAMMAD EBRAHIM

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Journal Paper

Paper Information

Journal: Archives of Medical Laboratory Sciences Year:2021 | Volume:7 | Issue:1 Page(s): 0-0

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Title

Sitagliptin Suppresses Apoptotic Cell Death and Histological Changes in the Ovaries of Rats with Polycystic Ovary Syndrome

Author(s)

Safaeian Azadeh | Zare Mehrjerdi Fatemeh | YADEGARI MARYAM | REZVANI MOHAMMAD EBRAHIM | Issue Writer Certificate

Keywords

Polycystic Ovary Syndrome

Apoptosis

Bcl-2

Bax

Sitagliptin

Abstract

Background and Aim: Polycystic Ovary Syndrome (PCOS) is the most typical endocrine disorder affecting reproductive-aged women. The patients with PCOS show decreased follicular granule cells' maturation in their ovaries, probably associated with cell Apoptosis. This study was designed to investigate Sitagliptin's protective effect against the apoptotic mechanism in PCOS via evaluating Apoptosis rate and the mRNA expressions of apoptotic and anti-apoptotic molecules in PCOS rats. Methods: PCOS was induced by injection of estradiol valerate (4 mg/kg, I. M. ). Twenty-two female rats divided into four groups: Control (n=5), PCOS+Vehicle (n=5), PCOS+ Sitagliptin 25 mg/kg (n=6) and PCOS+ Sitagliptin 50 mg/kg (n=6). Hematoxylin and eosin staining were used to determine qualitative changes in the ovary follicles. The apoptotic index was examined by TUNEL assay, and the quantitative polymerase chain reaction was performed to detect expression levels of Bax and Bcl-2. Results: Bax mRNA expression was up-regulated (1. 38-folds), and Bcl-2 mRNA expression was down-regulated (0. 45-folds) in PCOS rats' ovarian tissues. Sitagliptin did not change Bax expression but increased the Bcl-2 mRNA expression (1. 95-folds). The Apoptosis index was increased in the PCOS group compared with the control group. The number of cystic follicles and pre-antral follicles increased the number of corpus luteum was decreased in PCOS rats compared to control rats. Sitagliptin decreased Apoptosis rate and prevented the increase of cystic and pre-antral follicle numbers compared to the PCOS group. Conclusion: In conclusion, Sitagliptin might have a major role in preventing PCOS development due to its antiapoptotic properties on PCOS rats' ovaries.

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APA: Copy

Safaeian, Azadeh, Zare Mehrjerdi, Fatemeh, YADEGARI, MARYAM, & REZVANI, MOHAMMAD EBRAHIM. (2021). Sitagliptin Suppresses Apoptotic Cell Death and Histological Changes in the Ovaries of Rats with Polycystic Ovary Syndrome. ARCHIVES OF MEDICAL LABORATORY SCIENCES, 7(1), 0-0. SID. https://sid.ir/paper/1020180/en

Vancouver: Copy

Safaeian Azadeh, Zare Mehrjerdi Fatemeh, YADEGARI MARYAM, REZVANI MOHAMMAD EBRAHIM. Sitagliptin Suppresses Apoptotic Cell Death and Histological Changes in the Ovaries of Rats with Polycystic Ovary Syndrome. ARCHIVES OF MEDICAL LABORATORY SCIENCES[Internet]. 2021;7(1):0-0. Available from: https://sid.ir/paper/1020180/en

IEEE: Copy

Azadeh Safaeian, Fatemeh Zare Mehrjerdi, MARYAM YADEGARI, and MOHAMMAD EBRAHIM REZVANI, “Sitagliptin Suppresses Apoptotic Cell Death and Histological Changes in the Ovaries of Rats with Polycystic Ovary Syndrome,” ARCHIVES OF MEDICAL LABORATORY SCIENCES, vol. 7, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/1020180/en

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