The Effect of Hydroalcoholic Extract of Sativa Nigella and Honey on Liver Enzymes (AST, ALT, ALP) in Adult Male Rats Following Induction of Diabetes Mellitus

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZAEI ZEINAB; MOKHTARI MOKHTAR; SHARIATI MEHRDAD

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ALBORZ UNIVERSITY MEDICAL JOURNAL Year:2022 | Volume:11 | Issue:2 Page(s): 196-206

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

The Effect of Hydroalcoholic Extract of Sativa Nigella and Honey on Liver Enzymes (AST, ALT, ALP) in Adult Male Rats Following Induction of Diabetes Mellitus

Author(s)

REZAEI ZEINAB | MOKHTARI MOKHTAR | SHARIATI MEHRDAD | Issue Writer Certificate

Keywords

Sativa nigella

Honey

AST

ALT

ALP

Streptozotocin

Rat

Abstract

Propose: Diabetes is a metabolic disease associated with hypoglycemia, hypolipidemia, and liver dysfunction. The aim of this study was to evaluate the effects of hydroalcoholic extract of black seed and Honey (dozin) on liver enzymes (AST, ALT, ALP) in Streptozotocin-induced diabetic Rats. Material: 70 adult male Rats weighing approximately 220-200 g were divided into 7 groups: Control group: did not receive any medication. The sham group received only solvent. Experimental group 1 and 2: Animals in this group received 2 and 4 g / kg of hydroalcoholic extract of black seed and Honey (dosin), respectively. Experimental group 3 received Streptozotocin intraperitoneally as diabetic group: Animals in this group received 70 mg / kg of Streptozotocin intraperitoneally, experimental group 4 and 5, Animals in this group first received Streptozotocin and then 2 and 4 g / kg of extracts. Rats were treated for 21 days and at the end of the experimental period, blood samples were collected and serum levels of liver enzymes (AST, ALT, ALP) were measured. Findings: The results show that the levels of AST and ALP enzymes in experimental groups 5 and 4, respectively, compared with experimental group 3 (diabetic group l) and in experimental groups 1 and 2, compared with control and sham groups, showed a significant decrease at the level of p <0. 05. In experimental group 3 (diabetic group), the level s of AST and ALP enzymes showed a significant increase compared to control and sham groups. Conclusion: This study showed that the hydroalcoholic extract of black seed and Honey (dosine) probably improves the destructive effects of diabetes on changes in liver enzymes due to its antioxidant properties.

Cites

No record.

References

No record.

Cite

APA: Copy

REZAEI, ZEINAB, MOKHTARI, MOKHTAR, & SHARIATI, MEHRDAD. (2022). The Effect of Hydroalcoholic Extract of Sativa Nigella and Honey on Liver Enzymes (AST, ALT, ALP) in Adult Male Rats Following Induction of Diabetes Mellitus. ALBORZ UNIVERSITY MEDICAL JOURNAL, 11(2 ), 196-206. SID. https://sid.ir/paper/1020413/en

Vancouver: Copy

REZAEI ZEINAB, MOKHTARI MOKHTAR, SHARIATI MEHRDAD. The Effect of Hydroalcoholic Extract of Sativa Nigella and Honey on Liver Enzymes (AST, ALT, ALP) in Adult Male Rats Following Induction of Diabetes Mellitus. ALBORZ UNIVERSITY MEDICAL JOURNAL[Internet]. 2022;11(2 ):196-206. Available from: https://sid.ir/paper/1020413/en

IEEE: Copy

ZEINAB REZAEI, MOKHTAR MOKHTARI, and MEHRDAD SHARIATI, “The Effect of Hydroalcoholic Extract of Sativa Nigella and Honey on Liver Enzymes (AST, ALT, ALP) in Adult Male Rats Following Induction of Diabetes Mellitus,” ALBORZ UNIVERSITY MEDICAL JOURNAL, vol. 11, no. 2 , pp. 196–206, 2022, [Online]. Available: https://sid.ir/paper/1020413/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops