THE EFFECT OF AGE AT ONSET ON THE PROGNOSIS OF CHILDHOOD STEROID SENSITIVE NEPHROTIC SYNDROME

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DERAKHSHAN A.; HOSSEINI ALHASHEMI GH.; FALAHZADEH M.H.; BARDESTANI GH.R.

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Journal: Razi Journal of Medical Sciences Year:2004 | Volume:11 | Issue:39 Page(s): 31-38

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Title

THE EFFECT OF AGE AT ONSET ON THE PROGNOSIS OF CHILDHOOD STEROID SENSITIVE NEPHROTIC SYNDROME

Author(s)

DERAKHSHAN A. | HOSSEINI ALHASHEMI GH. | FALAHZADEH M.H. | BARDESTANI GH.R. | Issue Writer Certificate

Keywords

NEPHROTIC SYNDROMEQ3

CHILDRENQ3

AGE AT ONSETQ4

PROGNOSISQ4

RELAPSEQ2

Abstract

Minimal change NEPHROTIC SYNDROME (MCNS) is the most common form of Idiopathic NEPHROTIC SYNDROME (INS) in childhood. Although most of the CHILDREN with INS respond to steroid, a majority of them have subsequent RELAPSEs. In this study the effect of AGE AT ONSET on the outcome of steroid responsive NEPHROTIC SYNDROME (NS) was evaluated. Medical records of all CHILDREN with INS (1-10 years old) and initial response to steroid were reviewed. They had been followed for at least 7 years, and age of onset, sex, number of RELAPSEs, pathology report and other immunosuppressive therapy were considered. They were studied in 3 age groups: 1-3 years, 4-6 years and 7-10 years at the onset of NS. Sixty-one CHILDREN (46 boys and 15 girls) were included in this study. There were 23, 24 and 14 CHILDREN in the above-mentioned age groups respectively. Kidney biopsy had been done for 46 CHILDREN 76.5% of whom had MCNS. Cyclophosphamide, chlorambucil and cyclospurin had been used for 18.4 and 1 of them respectively. CHILDREN with onset of NS at 1-3, 4-6 and 7-10 years of age had (mean±SD) 7±5.92, 4.54±3.74 and 1.57±1.81 of RELAPSEs respectively. The duration of disease was also 5.52±4.15, 5.37±3.57 and 1.92±1.54 years respectively. Regarding the number of RELAPSEs and duration of disease, the differences between the 7-10 years age group and the other 2 groups were statistically significant (P<0.05). It can be concluded that AGE AT ONSET is a reliable predictor of the course and PROGNOSIS of childhood steroid-responsive NS.

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APA: Copy

DERAKHSHAN, A., HOSSEINI ALHASHEMI, GH., FALAHZADEH, M.H., & BARDESTANI, GH.R.. (2004). THE EFFECT OF AGE AT ONSET ON THE PROGNOSIS OF CHILDHOOD STEROID SENSITIVE NEPHROTIC SYNDROME. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 11(39), 31-38. SID. https://sid.ir/paper/10221/en

Vancouver: Copy

DERAKHSHAN A., HOSSEINI ALHASHEMI GH., FALAHZADEH M.H., BARDESTANI GH.R.. THE EFFECT OF AGE AT ONSET ON THE PROGNOSIS OF CHILDHOOD STEROID SENSITIVE NEPHROTIC SYNDROME. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2004;11(39):31-38. Available from: https://sid.ir/paper/10221/en

IEEE: Copy

A. DERAKHSHAN, GH. HOSSEINI ALHASHEMI, M.H. FALAHZADEH, and GH.R. BARDESTANI, “THE EFFECT OF AGE AT ONSET ON THE PROGNOSIS OF CHILDHOOD STEROID SENSITIVE NEPHROTIC SYNDROME,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 11, no. 39, pp. 31–38, 2004, [Online]. Available: https://sid.ir/paper/10221/en

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