MEASUREMENT OF THE ABSORBED DOSE OF RADIOPHARMACEUTICALS 

99MTC-EC AND 

99MTC-DTPA BY KIDNEY, LIVER, BLADDER AND OVARY IN RENAL SCINTIGRAPHY EXPERIMENTS USING WATER PHANTOM AND TLD DOSIMETRY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARAFI A.A.; HEKMAT S.; MORTEZAZADEH T.; MOVAHEDI MANSOUR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2010 | Volume:17 | Issue:74 Page(s): 33-42

Download Full-Text

Persian Verion

View:

1,311

Download:

Cites:

Information Journal Paper

Title

MEASUREMENT OF THE ABSORBED DOSE OF RADIOPHARMACEUTICALS 99MTC-EC AND 99MTC-DTPA BY KIDNEY, LIVER, BLADDER AND OVARY IN RENAL SCINTIGRAPHY EXPERIMENTS USING WATER PHANTOM AND TLD DOSIMETRY

Author(s)

SHARAFI A.A. | HEKMAT S. | MORTEZAZADEH T. | MOVAHEDI MANSOUR | Issue Writer Certificate

Keywords

ORGAN ABSORBED DOSEQ3

RENAL SCINTIGRAPHYQ3

THERMOLUMINESCENCE DOSIMETRYQ3

ANTROPOMORPHIC PHANTOMQ3

Abstract

Background: In this survey the absorbed dose by kidneys, bladder, liver and ovaries with 99mTc-EC (99mTc Ethylene dicysteine) RENAL SCINTIGRAPHY was measured and compared with the absorbed dose from 99mTc-DTPA (99mTc - Dietheylne Triamine Penta-Acid), which often is used in RENAL SCINTIGRAPHY. Methods: In this applicable study, we used a water phantom with geometrical sizes similar to that of human body and composed of thorax and hip. Then in accordance with International Committee on Radiation Protection ICRP -23, we placed kidney, liver, bladder and ovary phantoms in to the thorax and hip parts. For dosimetry 30 cubical Lithium fluoride chips (TLD-100) were used.By using different values of 99mTc-EC and 99mTc-DTPA distributed in different phantom parts, the absorbed doses in kidneys, liver, bladder and ovaries were measured. Then by measuring skin dose in the region of kidneys, bladder, liver and ovaries in 20 female patients (10 patients for each radioisotope) that were under renal scan, the absorbed doses of above mentioned organs using phantom results were calculated. Statistical software used was SPSS V.16 and statistical data analysis was done by One sample Kolmogorov-Smirnov and t-tests.Results: The results of skin and ORGAN ABSORBED DOSEs of kidneys, liver, bladder and ovaries showed a good linear regression. The relationship between organ dose and skin dose with total activity varied linearly. The results of ORGAN ABSORBED DOSE in patients that were under renal scan with both radiopharmaceuticals showed:- Bladder absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 4.42±0.98 mrad/mCi, 2.91±0.74 mrad/mCi (p=0.001).-Liver absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 2.44±0.44 mrad/mCi, 1.58±0.019 mrad/mCi (p=0.000).-Right kidney absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 4.04±1.06 mrad/mCi, 2.67±0.036 mrad/mCi (p=0.003).- Left kidney absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 4.11±0.93 mrad/mCi, 2.60±0.14 mrad/mCi (p=0.000).-Ovaries absorbed dose with 99mTc-DTPA and 99mTc-EC respectively were: 2.55±0.28 mrad/mCi, .62±0.025 mrad/mCi (p=0.000).Conclusion: The results of this study showed that in patients under renal scan with 99mTc-EC, absorbed dose by kidneys, liver, bladder and ovaries is considerably lower than those with 99mTc-DTPA. Also as 99mTc-EC has several other advantages such as: easily prepared, cheap, lower hepatic uptake, produces high quality images and has high renal excretion as compared to 99mTc-DTPA, thus it could be used more in radioisotopic renal scan in nuclear medicine clinics.

Cites

No record.

References

No record.

Cite

APA: Copy

SHARAFI, A.A., HEKMAT, S., MORTEZAZADEH, T., & MOVAHEDI, MANSOUR. (2010). MEASUREMENT OF THE ABSORBED DOSE OF RADIOPHARMACEUTICALS ^99MTC-EC AND ^99MTC-DTPA BY KIDNEY, LIVER, BLADDER AND OVARY IN RENAL SCINTIGRAPHY EXPERIMENTS USING WATER PHANTOM AND TLD DOSIMETRY. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 17(74), 33-42. SID. https://sid.ir/paper/10290/en

Vancouver: Copy

SHARAFI A.A., HEKMAT S., MORTEZAZADEH T., MOVAHEDI MANSOUR. MEASUREMENT OF THE ABSORBED DOSE OF RADIOPHARMACEUTICALS ^99MTC-EC AND ^99MTC-DTPA BY KIDNEY, LIVER, BLADDER AND OVARY IN RENAL SCINTIGRAPHY EXPERIMENTS USING WATER PHANTOM AND TLD DOSIMETRY. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2010;17(74):33-42. Available from: https://sid.ir/paper/10290/en

IEEE: Copy

A.A. SHARAFI, S. HEKMAT, T. MORTEZAZADEH, and MANSOUR MOVAHEDI, “MEASUREMENT OF THE ABSORBED DOSE OF RADIOPHARMACEUTICALS ^99MTC-EC AND ^99MTC-DTPA BY KIDNEY, LIVER, BLADDER AND OVARY IN RENAL SCINTIGRAPHY EXPERIMENTS USING WATER PHANTOM AND TLD DOSIMETRY,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 17, no. 74, pp. 33–42, 2010, [Online]. Available: https://sid.ir/paper/10290/en

Related Journal Papers