Comparison of the Effect of Two type of High Intensity Interval Training on the Expression Genes of IRS-1 and IRE-1α,in the Cardiomyosytes type 2 diabetes of Obes Male Rats

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Babaei Sedigheh; PEERI MAGHSOUD; AZARBAYJANI MOHAMMAD ALI; DELFAN MARYAM

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Journal Paper

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2021 | Volume:64 | Issue:3 Page(s): 3131-3142

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Title

Comparison of the Effect of Two type of High Intensity Interval Training on the Expression Genes of IRS-1 and IRE-1α,in the Cardiomyosytes type 2 diabetes of Obes Male Rats

Author(s)

Babaei Sedigheh | PEERI MAGHSOUD | AZARBAYJANI MOHAMMAD ALI | DELFAN MARYAM | Issue Writer Certificate

Keywords

High Intensity Interval Training

IRS-1

IRE-1α

Type 2 Diabetes

Abstract

Introduction: Regular interval training with adaption volume regulated genes expression in diabetic pations and reduced cardiomyopathy. Background: The purpose of this study was Comparison Comparison the Effect of Two types of High-Intensity Interval Training on the Expression Genes of IRS-1 and IRE-1α,in the Cardiomyocytes Type 2 Diabetes of Obes Male Rats. Methods: 36 male Wistar rats were divided into 4 groups: type1 highintensity interval training (HIIT1: 1), type2 high-intensity interval training (HIIT2: 1), diabetic control (DC), and nondiabetic control (NC) trained fo 4 weeks and 5 days/week. Plasma glucose concentration was measured by the glucose oxidase method. ELISA method was used to measure the insulin levels and the HOMA-IR method was used to measure insulin resistance index. A real-time PCR technique was used to evaluate the gene expression of the IRS-1 and IRE-1α,genes. Results were analyzed with one-way ANOVA and Tukey post hoc tests at the alpha level of 0/05. Diabetes induced by STZ in diabetic groups. Results: gene expression of IRS-1 in both groups of HIIT2: 1(p= 0. 002) and HIIT1: 1(p= 0. 006) showed a significant decrease compared to the DC group and in HIIT2: 1(P=0/043) showed a significant decrease compared to the HIIT1: 1 group. a gene of IRE-1α,in both groups of HIIT2: 1(p= 0. 005) and HIIT1: 1(p= 0. 007) showed a significant decrease compared to the DC group and in HIIT2: 1(P=0/001) showed a significant decrease compared to the HIIT1: 1 group. The mean weight values and insulin resistance index in the HIIT1: 1 group and glucose were significantly lower in the HIIT2: 1 group. Conclusion: 4 weeks High-intensity interval training type 2 with a higher effect on decreasing IRS-1 and IRE-1α,genes expression in cardiomyocytes of obese diabetic rats may it can improve gene dysregulation.

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APA: Copy

Babaei, Sedigheh, PEERI, MAGHSOUD, AZARBAYJANI, MOHAMMAD ALI, & DELFAN, MARYAM. (2021). Comparison of the Effect of Two type of High Intensity Interval Training on the Expression Genes of IRS-1 and IRE-1α,in the Cardiomyosytes type 2 diabetes of Obes Male Rats. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 64(3 ), 3131-3142. SID. https://sid.ir/paper/1029612/en

Vancouver: Copy

Babaei Sedigheh, PEERI MAGHSOUD, AZARBAYJANI MOHAMMAD ALI, DELFAN MARYAM. Comparison of the Effect of Two type of High Intensity Interval Training on the Expression Genes of IRS-1 and IRE-1α,in the Cardiomyosytes type 2 diabetes of Obes Male Rats. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;64(3 ):3131-3142. Available from: https://sid.ir/paper/1029612/en

IEEE: Copy

Sedigheh Babaei, MAGHSOUD PEERI, MOHAMMAD ALI AZARBAYJANI, and MARYAM DELFAN, “Comparison of the Effect of Two type of High Intensity Interval Training on the Expression Genes of IRS-1 and IRE-1α,in the Cardiomyosytes type 2 diabetes of Obes Male Rats,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 64, no. 3 , pp. 3131–3142, 2021, [Online]. Available: https://sid.ir/paper/1029612/en

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