Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran

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Ebrahimi Behnam Baharak; KHALAJ KONDORI MOHAMMAD; Hossein Pour Feizi Mohammad Ali

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Journal Paper

Paper Information

Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2021 | Volume:26 | Issue:6 (116) Page(s): 69-82

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Information Journal Paper

Title

Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran

Author(s)

Ebrahimi Behnam Baharak | KHALAJ KONDORI MOHAMMAD | Hossein Pour Feizi Mohammad Ali | Issue Writer Certificate

Keywords

HLA-G antigens

recurrent miscarriage

Single nucleotide polymorphism

Genetic association studies

Abstract

Background and Aim: Recurrent spontaneous abortion (RSA) is the most common complication of pregnancy that refers to two or more miscarriages before the 20 th week of pregnancy. HLA-G immunoglobulin molecule plays an important role in protecting the fetus against mother's immune system. The aim of this study was to investigate the association between rs1632943 and rs1736932 polymorphisms with recurrent spontaneous abortion in Northwest of Iran. Materials and Methods: This case-control study included 100 women with history of RSA as our case group and 80 healthy women with one or more than one children as the control group. Genomic DNA was purified from their peripheral blood samples and their genotypes were determined by PCR-sequencing method. Using SPSS 16, statistical analysis was performed by chi-square test. Results: In rs1632943 polymorphism the frequency of CC, CA and AA genotypes were 8%, 33% and 59% in the patient group and 16. 25%, 43. 75% and % 40 in the control group, respectively. Statistical analysis showed that AA genotype was associated with the recurrent spontaneous abortion (P = 0. 005). In the rs1736932 polymorphism, the frequency of CC, CG and GG genotypes were 8%, 32% and 60% in the patient group and 17. 5%, 41. 25% and 41. 25% in the control group, respectively. Statistical analysis showed that GG genotype was associated with the recurrent miscarriage (P = 0. 005). Also, haplotype analysis showed that H1 haplotype (GA) is associated with the disorder. Conclusion: Results of the study showed that rs1632943 and ra1736932 polymorphisms might be considered as risk factors for RSA in the women in Northwest of Iran.

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APA: Copy

Ebrahimi Behnam, Baharak, KHALAJ KONDORI, MOHAMMAD, & Hossein Pour Feizi, Mohammad Ali. (2022). Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 26(6 (116) ), 69-82. SID. https://sid.ir/paper/1031158/en

Vancouver: Copy

Ebrahimi Behnam Baharak, KHALAJ KONDORI MOHAMMAD, Hossein Pour Feizi Mohammad Ali. Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;26(6 (116) ):69-82. Available from: https://sid.ir/paper/1031158/en

IEEE: Copy

Baharak Ebrahimi Behnam, MOHAMMAD KHALAJ KONDORI, and Mohammad Ali Hossein Pour Feizi, “Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 6 (116) , pp. 69–82, 2022, [Online]. Available: https://sid.ir/paper/1031158/en

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