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Information Journal Paper

Title

Evaluation of BECLINE-1 and LC3 gene expression in endo metriosis rats following regular aerobic exercise and omega-3 in take

Pages

  50-57

Abstract

 Introduction: Endometriosis is a systemic endocrine, immunological and gastrointestinal disease. Various cellular pathways are involved in the pathogenesis of Endometriosis. One of these pathways is Autophagy. The aim of this study was to evaluate the expression of BECLINE-1 and LC3 genes in Endometriosis mice following regular Aerobic exercise and omega-3 in take. Methods: In this experimental study, 35 adult male Wistar rats were randomly divided into healthy control groups, Endometriosis, Endometriosis+exercise, Endometriosis+Omega 3, Endometriosis+omega3+exercise after creating an Endometriosis model. The duration of training in water was 30 minutes daily until the end of the training period. At the same time, the mice received omega-3 supplementation daily in the form of gavage at a dose of 2 ml / kg. One-way analysis of variance was applied to analyze the data. Results: The results showed that the expression of BECLINE-1 and LC3 gene in the Endometriosis group have a statistically signifi, cant increase compared to the healthy control group. All three groups of Endometriosis+exercise, Endometriosis+omega and Endometriosis+exercise+omega had a statistically signifi, cant decrease as compared to the Endometriosis group. The Endometriosis+exercise+omega group showed decrease more than the other groups. Conclusion: In general, the results of the present study indicate that the Authors: Zahra Rezaeei 1 Parvin Farzanegi* 2 Hajar Abbaszadeh 3 increased expression of autophagic genes produced in Endometriosis can be inhibited by regular Aerobic exercise such as swimming and also omega-3 supplementation. Pathological disorders in Autophagy with exercise and also omega-3 supplementation may help recovery Endometriosis by regulating the expression of LC3 and Beclin-1 genes.

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    Cite

    APA: Copy

    REZAEI, ZAHRA, FARZANEGI, PARVIN, & Abbaszadeh, Hajar. (2022). Evaluation of BECLINE-1 and LC3 gene expression in endo metriosis rats following regular aerobic exercise and omega-3 in take. JOURNAL OF NURSE AND PHYSICIAN WITHIN WAR, 10(34 ), 50-57. SID. https://sid.ir/paper/1032163/en

    Vancouver: Copy

    REZAEI ZAHRA, FARZANEGI PARVIN, Abbaszadeh Hajar. Evaluation of BECLINE-1 and LC3 gene expression in endo metriosis rats following regular aerobic exercise and omega-3 in take. JOURNAL OF NURSE AND PHYSICIAN WITHIN WAR[Internet]. 2022;10(34 ):50-57. Available from: https://sid.ir/paper/1032163/en

    IEEE: Copy

    ZAHRA REZAEI, PARVIN FARZANEGI, and Hajar Abbaszadeh, “Evaluation of BECLINE-1 and LC3 gene expression in endo metriosis rats following regular aerobic exercise and omega-3 in take,” JOURNAL OF NURSE AND PHYSICIAN WITHIN WAR, vol. 10, no. 34 , pp. 50–57, 2022, [Online]. Available: https://sid.ir/paper/1032163/en

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