THE EFFECT OF PHENYLALANINE METABOLITES ON THE BINDING OF HK-I (HEXOKINASE TYPE I) TO RAT´S BRAIN MITOCHONDRIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZIA MAJIDI N.; EHSANI ZONOUZ ABD ALVAHAB; FIROUZRAI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2007 | Volume:13 | Issue:53 Page(s): 127-133

Download Full-Text

Persian Verion

View:

912

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF PHENYLALANINE METABOLITES ON THE BINDING OF HK-I (HEXOKINASE TYPE I) TO RAT´S BRAIN MITOCHONDRIA

Author(s)

ZIA MAJIDI N. | EHSANI ZONOUZ ABD ALVAHAB | FIROUZRAI M. | Issue Writer Certificate

Keywords

HEXOKINASE TYPE IQ3

PHEYLKETONURIAQ2

PHENYLPYRUVIC ACIDQ3

BRAIN MITOCHONDRIAQ3

Abstract

Background & Aim: HEXOKINASE TYPE I is the most predominant form of the enzyme in brain. It binds reversibly to the outer mitochondria membrane. In normal condition the major part of the enzyme binds to the membrane. Membrane bound form of the enzyme is more active than the soluble form, so this is more a control mechanism of the enzyme activity. Those metabolites that affect the binding or releasing of the enzyme from the mitochondria have regulatory effect on glucose consumption of the cell. Since an increase in phenylalanine and its metabolites causes mental retardation in patients with phenylketonuria, we have studied the effects of these metabolites on the activity, binding and releasing of the enzyme to determine the destructive effect of these metabolites in relation to glucose metabolism in brain. Material & Method: This investigation was an experimental study in which hexokinase activity was determined spectrophotometrically by using G6PD (Glucose-6-Phosphate Dehydrogenase) coupled assay.Results: The results show that PHENYLPYRUVIC ACID decreases the enzyme activity in bound and soluble forms and increases the release of the enzyme from mitochondria whereas phenylalanine and phenyllactic acid have no effect on the enzyme activity, release and rebinding.Conclusion: It is possible that PHENYLPYRUVIC ACID causes the reduction of glucose consumption by decreasing hexokinase activity. Therefore, ATP (Adenosine Triphosphate) production declines in brain cells.

Cites

No record.

References

No record.

Cite

APA: Copy

ZIA MAJIDI, N., EHSANI ZONOUZ, ABD ALVAHAB, & FIROUZRAI, M.. (2007). THE EFFECT OF PHENYLALANINE METABOLITES ON THE BINDING OF HK-I (HEXOKINASE TYPE I) TO RAT´S BRAIN MITOCHONDRIA. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 13(53), 127-133. SID. https://sid.ir/paper/10347/en

Vancouver: Copy

ZIA MAJIDI N., EHSANI ZONOUZ ABD ALVAHAB, FIROUZRAI M.. THE EFFECT OF PHENYLALANINE METABOLITES ON THE BINDING OF HK-I (HEXOKINASE TYPE I) TO RAT´S BRAIN MITOCHONDRIA. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2007;13(53):127-133. Available from: https://sid.ir/paper/10347/en

IEEE: Copy

N. ZIA MAJIDI, ABD ALVAHAB EHSANI ZONOUZ, and M. FIROUZRAI, “THE EFFECT OF PHENYLALANINE METABOLITES ON THE BINDING OF HK-I (HEXOKINASE TYPE I) TO RAT´S BRAIN MITOCHONDRIA,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 13, no. 53, pp. 127–133, 2007, [Online]. Available: https://sid.ir/paper/10347/en

Related Journal Papers