Investigation of the Clinical Efficacy of 99mTc-SestamibiWashout in Patients with Acute Myocardial Infarction and Comparison with Stress Myocardial Imaging with 99mTc-Sestamibi Using a Two-Day Protocol

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Ota Mieko; Hyodo Fuminori; MATSUO SHINRO; KATO TAKASHI; Kawai Nobuyuki; Nakamura Fumihiko; Fujimoto Keita; Kaneko Yo; KATO HIROKI; Matsuo Masayuki

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Journal: Iranian Journal of Radiology Year:2022 | Volume:19 | Issue:AB0042 Page(s): 0-0

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Title

Investigation of the Clinical Efficacy of 99mTc-SestamibiWashout in Patients with Acute Myocardial Infarction and Comparison with Stress Myocardial Imaging with 99mTc-Sestamibi Using a Two-Day Protocol

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Keywords

99mTc-sestamibi (MIBI)

Washout

Two-day Protocol

Abstract

Background: 99mTc-sestamibimyocardial perfusion imaging (MIBI) Washout is associated withmyocardial mitochondrial damage in patients with a successful percutaneous coronary intervention (PCI) following acutemyocardial infarction (AMI) andmaypredict the functional improvement of the left ventricle in follow-ups. Objectives: This study aimed to investigate the clinical efficacy of 99mTc-MIBI Washout in patients with AMI by measuring the mean defect area based on 99mTc-MIBI myocardial perfusion-single photon emission computed tomography (MP-SPECT) rest imaging in early and delayed phases and comparing it with the defect area based on 99mTc-MIBI MP-SPECT adenosine stress imaging based on a two-day rest/stress protocol. Patients and Methods: This study was conducted on 29 consecutive patients with AMI (23 males and 6 females,mean age, 71, 8. 4 years), who underwent MP-SPECT using a standard two-day rest/stress protocol. The rest 99mTc-MIBI MP-SPECT images were acquired in the early phase at one hour after the injection of 99mTc-MIBI and in the delayed phase at three hours after the early phase. The total perfusion deficit (TPD) score for SPECT was measured to compare the defect area between the rest-early phase, rest-delayed phase, and post-stress imaging conditions. Results: Based on the results, the post-stress TPD score was significantly lower than the rest-delayed phase score (TPD: 22. 2% , 14. 3% vs. 27. 8% , 14. 0%,P < 0. 001). Also, the rest-early phase score was significantly lower than the rest-delayed phase score (TPD: 21. 5% ,14. 9% vs. 27. 8% , 14. 0%,P < 0. 001). However, no significant difference was observed between the post-stress score and the rest-early phase score. Conclusion: The combination of rest-early phase, delayed phase, and post-stress 99mTc-MIBI imaging using a Two-day Protocol after AMI reperfusion was a clinically useful method, which could identify residual ischemia and predict the left ventricular function improvement in the chronic phase of disease while reducing the exposure dose.

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APA: Copy

Ota, Mieko, Hyodo, Fuminori, MATSUO, SHINRO, KATO, TAKASHI, Kawai, Nobuyuki, Nakamura, Fumihiko, Fujimoto, Keita, Kaneko, Yo, KATO, HIROKI, & Matsuo, Masayuki. (2022). Investigation of the Clinical Efficacy of 99mTc-SestamibiWashout in Patients with Acute Myocardial Infarction and Comparison with Stress Myocardial Imaging with 99mTc-Sestamibi Using a Two-Day Protocol. IRANIAN JOURNAL OF RADIOLOGY, 19(2), 0-0. SID. https://sid.ir/paper/1036167/en

Vancouver: Copy

Ota Mieko, Hyodo Fuminori, MATSUO SHINRO, KATO TAKASHI, Kawai Nobuyuki, Nakamura Fumihiko, Fujimoto Keita, Kaneko Yo, KATO HIROKI, Matsuo Masayuki. Investigation of the Clinical Efficacy of 99mTc-SestamibiWashout in Patients with Acute Myocardial Infarction and Comparison with Stress Myocardial Imaging with 99mTc-Sestamibi Using a Two-Day Protocol. IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2022;19(2):0-0. Available from: https://sid.ir/paper/1036167/en

IEEE: Copy

Mieko Ota, Fuminori Hyodo, SHINRO MATSUO, TAKASHI KATO, Nobuyuki Kawai, Fumihiko Nakamura, Keita Fujimoto, Yo Kaneko, HIROKI KATO, and Masayuki Matsuo, “Investigation of the Clinical Efficacy of 99mTc-SestamibiWashout in Patients with Acute Myocardial Infarction and Comparison with Stress Myocardial Imaging with 99mTc-Sestamibi Using a Two-Day Protocol,” IRANIAN JOURNAL OF RADIOLOGY, vol. 19, no. 2, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1036167/en

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