The Effect of Valproate Sodium on the Electrical Activity of Helix aspersa F1 Neurons in a Pentylenetetrazole-Induced Epileptic Model Using an Intracellular Recording System

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Ganjkhane Mahin; MARAHEM MARZIEH; PARIZAD MOHAMMAD AMIN; BEHESHTIROUY SAMAD

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Journal Paper

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Journal: Archives of Neuroscience Year:2022 | Volume:9 | Issue:1 Page(s): 0-0

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Title

The Effect of Valproate Sodium on the Electrical Activity of Helix aspersa F1 Neurons in a Pentylenetetrazole-Induced Epileptic Model Using an Intracellular Recording System

Author(s)

Ganjkhane Mahin | MARAHEM MARZIEH | PARIZAD MOHAMMAD AMIN | BEHESHTIROUY SAMAD | Issue Writer Certificate

Keywords

Valproate Sodium

Pentylenetetrazol

Snail Neurons

Intracellular Recording

Abstract

Background: Epilepsy is a chronic central nervous system disorder with a high prevalence in modern society. Despite using common anticonvulsant drugs, its control is not adequately achieved. Animal models for seizures play the leading role in advancing our understanding of the cellular mechanisms of epilepsy. The present study was an attempt to elucidate the electrophysiological mechanism of the effect of sodium valproate on the cellular model of epilepsy. Understanding the cellular mechanisms of this drug may help clarify the pharmacological screening of other drugs. Methods: The Intracellular Recording was made from F1 cells of garden Helix aspersa in the presence of Ringer solution. Following the extracellular application of Valproate Sodium at a concentration of 10 mM after and before the use of (25mM) epileptogenic agent (Pentylenetetrazol (PTZ)), we evaluated its effect on paroxysmal depolarization shift (PDS) and electrophysiological characteristics. Results: These results showed that Valproate Sodium could reduce neuronal excitability. It could significantly hyperpolarize rest action potential by decreasing the frequency of firing rate and increasing the amplitude of afterhyperpolarization (AHP) and can prevent depolarization of rest action potential by PTZ. Conclusions: The results suggested that Valproate Sodium could reduce the PTZ-induced hyperexcitation by hyperpolarization of resting membrane potential (RMP), a reduction in AHP amplitude, and firing the frequency.

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APA: Copy

Ganjkhane, Mahin, MARAHEM, MARZIEH, PARIZAD, MOHAMMAD AMIN, & BEHESHTIROUY, SAMAD. (2022). The Effect of Valproate Sodium on the Electrical Activity of Helix aspersa F1 Neurons in a Pentylenetetrazole-Induced Epileptic Model Using an Intracellular Recording System. ARCHIVES OF NEUROSCIENCE, 9(1), 0-0. SID. https://sid.ir/paper/1038465/en

Vancouver: Copy

Ganjkhane Mahin, MARAHEM MARZIEH, PARIZAD MOHAMMAD AMIN, BEHESHTIROUY SAMAD. The Effect of Valproate Sodium on the Electrical Activity of Helix aspersa F1 Neurons in a Pentylenetetrazole-Induced Epileptic Model Using an Intracellular Recording System. ARCHIVES OF NEUROSCIENCE[Internet]. 2022;9(1):0-0. Available from: https://sid.ir/paper/1038465/en

IEEE: Copy

Mahin Ganjkhane, MARZIEH MARAHEM, MOHAMMAD AMIN PARIZAD, and SAMAD BEHESHTIROUY, “The Effect of Valproate Sodium on the Electrical Activity of Helix aspersa F1 Neurons in a Pentylenetetrazole-Induced Epileptic Model Using an Intracellular Recording System,” ARCHIVES OF NEUROSCIENCE, vol. 9, no. 1, pp. 0–0, 2022, [Online]. Available: https://sid.ir/paper/1038465/en

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