Comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women

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RAJABI ALI; SIAHKOUHIAN MAREFAT; AKBARNEJAD ALI

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:166 Page(s): 20-33

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Title

Comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women

Author(s)

RAJABI ALI | SIAHKOUHIAN MAREFAT | AKBARNEJAD ALI | Issue Writer Certificate

Keywords

Type 2 diabetesQ2

Aerobic exerciseQ2

SaffronQ2

IL-6Q2

TNF-asQ1

Abstract

Background: The purpose of this study was comparison of the effect of a therapeutic exercise program and oral administration of Saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women Methods: 48 type 2 diabetic obese women were randomly divided into four equal groups (Saffron + training, training + placebo, Saffron, placebo). The Saffron group + training and training + placebo groups performed aerobic training with intensity of 60-75% of maximal heart rate for 8 weeks (three sessions per week). Daily dose of 400 mg of Saffron sprout powder (once a day) was used for two months. The placebo contained 400 mg of wheat flour. The following IL-6, TNF-a, Blood glucose and HbA1c variables; lipid profiles and HOMA-IR were tested. The Shapiro-Wilk test, variance analysis with repeated measures, Bonferron's post hoc test, and one way analysis of variance with LSD post-test. Results: In the post-test phase, the pre-test the variables IL-6 and TNF-α , blood glucose and HbA1c in intervention groups decreased significantly, and also in the post-test between group, Saffron + training with training + placebo, Saffron + training with Saffron, Saffron + training with placebo and Saffron with placebo there was a significant difference (p<0. 05). Also, in variables of weight and BMI, there were statistically significant differences between Saffron + training with placebo groups, training + placebo with placebo groups, and Saffron with the placebo groups (p<0. 05). Conclusion: It can be possible Aerobic exercise and Saffron consumption have a protective effect against the increased levels of blood glucose and HbA1c. It is possible that the reduction of blood glucose, IL-6 and TNF-a in Saffron recipients is due to the presence of Saffron metabolites, especially flavonoids (crostein and crocin) and increased antioxidant defense system through Saffron.

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APA: Copy

RAJABI, ALI, SIAHKOUHIAN, MAREFAT, & AKBARNEJAD, ALI. (2018). Comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(166 ), 20-33. SID. https://sid.ir/paper/10386/en

Vancouver: Copy

RAJABI ALI, SIAHKOUHIAN MAREFAT, AKBARNEJAD ALI. Comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(166 ):20-33. Available from: https://sid.ir/paper/10386/en

IEEE: Copy

ALI RAJABI, MAREFAT SIAHKOUHIAN, and ALI AKBARNEJAD, “Comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 166 , pp. 20–33, 2018, [Online]. Available: https://sid.ir/paper/10386/en

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