SEROLOGIC AND ELECTROPHYSIOLOGIC EVALUATION OF PATIENTS WITH MYASTHENIA GRAVIS

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VAHABI ZAHRA; NAFISI SHAHRIAR; SAFARIAN FATEMEH; SAFARIAN ZAHRA; AMIRZARGAR ALI AKBAR; SOLTANZADEH AKBAR; SIKARODI HAJIR

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Journal: Razi Journal of Medical Sciences Year:2012 | Volume:19 | Issue:105 Page(s): 10-16

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Title

SEROLOGIC AND ELECTROPHYSIOLOGIC EVALUATION OF PATIENTS WITH MYASTHENIA GRAVIS

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Keywords

MYASTHENIA GRAVISQ2

ACHR-ABQ3

RNSQ2

Abstract

Background: MYASTHENIA GRAVIS is an autoimmune disorder mainly caused by antibodies to the muscle acetylcholine receptors (AChR-Ab) at the neuromuscular junction. Loss of these receptors leads to a defect in neuromuscular transmission with muscle weakness and fatigue. This antibody is not detected in all the patients and electrophysiologic study is necessary in some patients as a diagnostic tool. The serologic and electrophysiologic tests in MYASTHENIA GRAVIS are evaluated in this study.Methods: One hundred twelve patients entered in a cross-sectional study. Serum ACHR-AB was measured andRepetitive nerve stimulation (RNS) was done. The frequency of positive ACHR-AB and abnormal RNS and the relationship between them were determined.Results: Thirty (26.8%) patients were males and 82 (73.2%) were females. Mean of age was 37.6±15.4 years. ACHR-AB was positive in 71 (63.4%) and negative in 41 (36.6%). RNS was done in 101 patients and was abnormal in 74 (73.3%) and normal in 27 (26.7%) patients. Ratio of abnormal RNS was 84.4% and 53.7% in seropositive and seronegative patients, respectively (p=0.001).Conclusion: There is significant relationship between serologic and electrophysiological findings in MYASTHENIA GRAVIS. Combining electrophysiological and serological tests could increase the accuracy of MYASTHENIA GRAVIS diagnosis.

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APA: Copy

VAHABI, ZAHRA, NAFISI, SHAHRIAR, SAFARIAN, FATEMEH, SAFARIAN, ZAHRA, AMIRZARGAR, ALI AKBAR, SOLTANZADEH, AKBAR, & SIKARODI, HAJIR. (2012). SEROLOGIC AND ELECTROPHYSIOLOGIC EVALUATION OF PATIENTS WITH MYASTHENIA GRAVIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 19(105), 10-16. SID. https://sid.ir/paper/10396/en

Vancouver: Copy

VAHABI ZAHRA, NAFISI SHAHRIAR, SAFARIAN FATEMEH, SAFARIAN ZAHRA, AMIRZARGAR ALI AKBAR, SOLTANZADEH AKBAR, SIKARODI HAJIR. SEROLOGIC AND ELECTROPHYSIOLOGIC EVALUATION OF PATIENTS WITH MYASTHENIA GRAVIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2012;19(105):10-16. Available from: https://sid.ir/paper/10396/en

IEEE: Copy

ZAHRA VAHABI, SHAHRIAR NAFISI, FATEMEH SAFARIAN, ZAHRA SAFARIAN, ALI AKBAR AMIRZARGAR, AKBAR SOLTANZADEH, and HAJIR SIKARODI, “SEROLOGIC AND ELECTROPHYSIOLOGIC EVALUATION OF PATIENTS WITH MYASTHENIA GRAVIS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 19, no. 105, pp. 10–16, 2012, [Online]. Available: https://sid.ir/paper/10396/en

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