EVALUATION OF BCL-2 EXPRESSION IN AGGRESSIVE AND NON-AGGRESSIVE BASAL CELL CARCINOMAS

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Salehian Dardashti p.; AMINI E.

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Journal: Razi Journal of Medical Sciences Year:2004 | Volume:11 | Issue:40 Page(s): 239-246

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Title

EVALUATION OF BCL-2 EXPRESSION IN AGGRESSIVE AND NON-AGGRESSIVE BASAL CELL CARCINOMAS

Author(s)

Salehian Dardashti p. | AMINI E. | Issue Writer Certificate

Keywords

BCL-2Q4

BCCQ2

ONCOGENEQ1

APOPTOSISQ1

Abstract

BCL-2, a well-known anti-apoptotic gene, promotes cell viability without cell proliferation. Expression of the BCL-2 ONCOGENE is reported in certain low grade neoplasms including Basal Cell Carcinomas (BCCs). BCL-2 expression in BCCs is contradictory, with 67-100% immunopositivity being reported. The purpose of this study was to evaluate BCL-2 expression in the indolent variants of BCC, namely superficial and circumscribed subtypes and their aggressive counterparts; infiltrative and morphea-like subtypes. Anti-human BCL-2 monoclonal antibody was used to identify its protein product in formalin-fixed tissue from 33 BCCs. 22 histophathologically non-aggressive and 11 aggressive subtypes were investigated. Quantity of decoration of tumor cells for BCL-2 was graded in the following fashion: 0 to 25%, 26% to 50%, 51% to 75%, 76% to 100%. Intensity of decoration was evaluated as slight, moderate and intense. BCL-2 expression was observed in all of the BCCs, but high BCL-2 expression was statistically a significant feature of non-aggressive BCCs (P=0.001). Different BCL-2 expression in various non-aggressive and aggressive histopathological subtypes of BCCs suggests that despite the common derivation of these tumors from a primitive basaloid stem cell and a limited potential for metastasis, they form a heterogeneous group of tumors. While the superficial and circumscribed BCCs are indolent slow-growing tumors with high BCL-2 labeling, the aggressive BCCs are infiltrative and morphea-like tumors with low BCL-2 labeling. High expression of BCL-2 may indicate a more favorable prognosis in BCCs.

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APA: Copy

Salehian Dardashti, p., & AMINI, E.. (2004). EVALUATION OF BCL-2 EXPRESSION IN AGGRESSIVE AND NON-AGGRESSIVE BASAL CELL CARCINOMAS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 11(40), 239-246. SID. https://sid.ir/paper/10400/en

Vancouver: Copy

Salehian Dardashti p., AMINI E.. EVALUATION OF BCL-2 EXPRESSION IN AGGRESSIVE AND NON-AGGRESSIVE BASAL CELL CARCINOMAS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2004;11(40):239-246. Available from: https://sid.ir/paper/10400/en

IEEE: Copy

p. Salehian Dardashti, and E. AMINI, “EVALUATION OF BCL-2 EXPRESSION IN AGGRESSIVE AND NON-AGGRESSIVE BASAL CELL CARCINOMAS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 11, no. 40, pp. 239–246, 2004, [Online]. Available: https://sid.ir/paper/10400/en

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