THE ASSESSMENT OF 5-AMINOSALICYLIC ACID(5-ASA) EFFECT ON ISCHEMIA- REPERFUSION INJURY OF THE KIDNEY IN RATS

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PAZOUKI TOROUDI H.R.; HOMAYOUN FAR HOMAYOUN; BANAEI GIVI SH.

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Journal: Razi Journal of Medical Sciences Year:2005 | Volume:12 | Issue:48 (SPECIAL ISSUE) Page(s): 63-68

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Title

THE ASSESSMENT OF 5-AMINOSALICYLIC ACID(5-ASA) EFFECT ON ISCHEMIA- REPERFUSION INJURY OF THE KIDNEY IN RATS

Author(s)

PAZOUKI TOROUDI H.R. | HOMAYOUN FAR HOMAYOUN | BANAEI GIVI SH. | Issue Writer Certificate

Keywords

5-AMINOSALICYLIC ACID(5-ASA)- REPERFUSION INJURY - NITRIC OXIDEQ4

Abstract

Background & Aim: Occlusion of organs artery results in ischemia and the opening of occluded artery leads to tissue lesion identified as reperfusion injury(RI). Oxygen-derived free radicals seem to be involved in the reperfusion injury. In this experimental study the effects of 5-aminosalicylic acid(5-ASA), a prescribed drug for ulcerative colitis, was assessed. 5-ASA is a potent scavenger of oxygen-derived free radicals in the RI of the kidney in a uninephrectomized rat model. Materials & Methods: Male Wistar rats of 200-250g were pretreated with 5-ASA(300mg/kg). Ischemiareperfusion(IR) injury was induced by left renal artery clipping for 45 min plus 24 or 48h reperfusion, while the right kidney was being removed. After 24 or 48h of IR injury, creatinine and nitric oxide(NO) levels in serum and urine, as the main parameters for evaluating of renal function, were determined. Results: After 24h of IR injury, 5-ASA(300mg/kg) not only obviously increased the levels of serum creatinine but also decreased the content of urinary creatinine and serum nitric oxide compard with the control group(P<0.05-0.0001). Whereas after 48h of IR injury, 5-ASA(300mg/kg) had no obvious effects on these parameters.Conclusion: 5-ASA(300mg/kg) used I.P 24h prior to the initiation of RI, in a time-depend ent manner, induced nephrotoxicity. Further studies on renal biopsy, laboratory findings and immunofluorescence microscopy for assessment of mechanisms involved in 5-ASA renal toxicity is suggested.

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APA: Copy

PAZOUKI TOROUDI, H.R., HOMAYOUN FAR, HOMAYOUN, & BANAEI GIVI, SH.. (2005). THE ASSESSMENT OF 5-AMINOSALICYLIC ACID(5-ASA) EFFECT ON ISCHEMIA- REPERFUSION INJURY OF THE KIDNEY IN RATS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 12(48 (SPECIAL ISSUE)), 63-68. SID. https://sid.ir/paper/10424/en

Vancouver: Copy

PAZOUKI TOROUDI H.R., HOMAYOUN FAR HOMAYOUN, BANAEI GIVI SH.. THE ASSESSMENT OF 5-AMINOSALICYLIC ACID(5-ASA) EFFECT ON ISCHEMIA- REPERFUSION INJURY OF THE KIDNEY IN RATS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2005;12(48 (SPECIAL ISSUE)):63-68. Available from: https://sid.ir/paper/10424/en

IEEE: Copy

H.R. PAZOUKI TOROUDI, HOMAYOUN HOMAYOUN FAR, and SH. BANAEI GIVI, “THE ASSESSMENT OF 5-AMINOSALICYLIC ACID(5-ASA) EFFECT ON ISCHEMIA- REPERFUSION INJURY OF THE KIDNEY IN RATS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 12, no. 48 (SPECIAL ISSUE), pp. 63–68, 2005, [Online]. Available: https://sid.ir/paper/10424/en

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