A STUDY ON THE EFFECT OF ORAL D-PENICILLAMINEON INTRAPERITONEAL ADHESION BANDS IN AN ANIMAL MODEL AND COMPARISON WITH COLCHICINE

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NIK EGHBALIAN S.; KAZEMI KOROUSH; TANIDEH N.; ROUSHAN N.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2003 | Volume:2 | Issue:1 Page(s): 1-6

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Title

A STUDY ON THE EFFECT OF ORAL D-PENICILLAMINEON INTRAPERITONEAL ADHESION BANDS IN AN ANIMAL MODEL AND COMPARISON WITH COLCHICINE

Author(s)

NIK EGHBALIAN S. | KAZEMI KOROUSH | TANIDEH N. | ROUSHAN N. | Issue Writer Certificate

Keywords

PERITONEAL ADHESION BANDQ4

COLCHICINEQ4

D-PENICILLAMINEQ4

Abstract

Background: The most common cause of intraPERITONEAL ADHESION BANDs is previous abdominal surgery. Postoperative adhesion formation results from a fibroproliferative inflammatory reaction. The possiblity of involvement of fibrogenic processes in adhesion formation and the anti-fibrogenic effect of D-PENICILLAMINE led us to test the effectiveness of this drug as a possible preventive measure for intraperitoneal adhesions. Materials and Methods: Eighty female rats were randomly divided into four equal groups of 20 rats. Intraabdominal adhesion bands were produced by intraperitoneal injection of 2.5 milliliter of a 10% sterile talc solution. The first group served as control, Group II received oral D-PENICILLAMINE 35 milligram per kilogram of body weight per day, Group III received oral COLCHICINE 0.02 milligram per kilogram per day and Group IV received both drugs for three weeks. Formation of adhesion bands was then quantitatively graded in each group according to Nair classification. Results: Severe adhesions (grades 3 and 4) were found in 20% of the D-PENICILLAMINE administered group (Group II), whereas these types of adhesions were observed in 33% and 84% of the COLCHICINE administered group (Group III) and the control group (Group I), respectively (p=0.003). Group IV, that had received both Dpenicillamine and COLCHICINE, was omitted from the study due to a high mortality rate. Adhesion bands in the Dpenicillamine group were thinner and smoother in comparison to other groups. Conclusion: Lower grades ofadhesion were found in the D-PENICILLAMINE group in comparison to the COLCHICINE and control groups. Therefore, it appears that D-PENICILLAMINE may be effective in the prevention of formation of adhesions in the rat.

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APA: Copy

NIK EGHBALIAN, S., KAZEMI, KOROUSH, TANIDEH, N., & ROUSHAN, N.. (2003). A STUDY ON THE EFFECT OF ORAL D-PENICILLAMINEON INTRAPERITONEAL ADHESION BANDS IN AN ANIMAL MODEL AND COMPARISON WITH COLCHICINE. JOURNAL OF MEDICAL RESEARCH (JMR), 2(1), 1-6. SID. https://sid.ir/paper/105782/en

Vancouver: Copy

NIK EGHBALIAN S., KAZEMI KOROUSH, TANIDEH N., ROUSHAN N.. A STUDY ON THE EFFECT OF ORAL D-PENICILLAMINEON INTRAPERITONEAL ADHESION BANDS IN AN ANIMAL MODEL AND COMPARISON WITH COLCHICINE. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2003;2(1):1-6. Available from: https://sid.ir/paper/105782/en

IEEE: Copy

S. NIK EGHBALIAN, KOROUSH KAZEMI, N. TANIDEH, and N. ROUSHAN, “A STUDY ON THE EFFECT OF ORAL D-PENICILLAMINEON INTRAPERITONEAL ADHESION BANDS IN AN ANIMAL MODEL AND COMPARISON WITH COLCHICINE,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 2, no. 1, pp. 1–6, 2003, [Online]. Available: https://sid.ir/paper/105782/en

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