COMPARISON OF EARLY VERSUS LATE POST-OPERATIVE ENTERAL FEEDING AFTER COLON ANASTOMOSIS IN RABBITS

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MALEKHOSSEINI A.; NIK EGHBALIAN S.; MONABATI A.; TANIDEH N.; KHAJEH R.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2004 | Volume:3 | Issue:1 Page(s): 31-36

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Title

COMPARISON OF EARLY VERSUS LATE POST-OPERATIVE ENTERAL FEEDING AFTER COLON ANASTOMOSIS IN RABBITS

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Keywords

EARLY FEEDINGQ4

LATE FEEDINGQ4

ANASTOMOSISQ3

LARGE BOWELQ4

Abstract

Background: One of the most common surgical procedures is colorectal surgery and subsequent colectomy and ANASTOMOSIS. Oral intake has usually been withheld for these patients for several days after operation which causes impairment in healing of the ANASTOMOSIS due to mucosal atrophy and reduction of immune capacity of the bowel. Also, it increases the possibility of post-operative complications such as prolonged ileus and intra-peritoneal adhesion. This study compares early and late-onset postoperative enteral feeding after colon ANASTOMOSIS in rabbits. Materials and Methods: This study was carried out in an animal laboratory during a 5-monthperiod on 30 rabbits that were randomly divided into two equal groups of 15 rabbits, Group I as the control group and Group II as the case group. All the rabbits had a pre-operative mechanical bowel preparation by ingestion of milk of magnesium, and then, they were anesthetized and underwent laparatomy, cutting of the transverse colon, and end-to-end ANASTOMOSIS. Oral intake was started 72 hours after surgery in Group I (control) and 12 hours after surgery in Group II (case). At the tenth post-operative day, all the rabbits underwent autopsy and the sites of ANASTOMOSIS were examined for assessment of the healing process and evidence of leakage and the peritoneal cavity was checked for adhesions. The anastomotic segments were removed for histopathological evaluation. Results: The frequency of anastomotic leakage at the site of ANASTOMOSIS and subsequent death were 6.6 percent in Group I and zero in Group II. All of the rabbits in Group II tolerated oral feeding after 12 hours. Autopsy of the rabbits showed intra-peritoneal adhesion in Group I, which was very severe in 14.2 percent, severe in 21.4 percent, moderate in 25.7 percent and minimal in 28.5 percent. In Group II, the severity of adhesion was as follows; no case with very severe adhesion, severe in 20 percent, moderate in 26.6 percent and minimal in 53.3 percent (p<0.05). The histopathological study showed complete healing in two-thirds of the samples in both groups (64.2 percent in Group I and 66.6 percent in Group II) and the remaining had partial healing. Conclusion: Early oral feeding after colon ANASTOMOSIS not only has a favorite effect on anastomotic healing but also may reduce post-operative complications such as leakage at the site of repair and adhesion band formation.

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APA: Copy

MALEKHOSSEINI, A., NIK EGHBALIAN, S., MONABATI, A., TANIDEH, N., & KHAJEH, R.. (2004). COMPARISON OF EARLY VERSUS LATE POST-OPERATIVE ENTERAL FEEDING AFTER COLON ANASTOMOSIS IN RABBITS. JOURNAL OF MEDICAL RESEARCH (JMR), 3(1), 31-36. SID. https://sid.ir/paper/105794/en

Vancouver: Copy

MALEKHOSSEINI A., NIK EGHBALIAN S., MONABATI A., TANIDEH N., KHAJEH R.. COMPARISON OF EARLY VERSUS LATE POST-OPERATIVE ENTERAL FEEDING AFTER COLON ANASTOMOSIS IN RABBITS. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2004;3(1):31-36. Available from: https://sid.ir/paper/105794/en

IEEE: Copy

A. MALEKHOSSEINI, S. NIK EGHBALIAN, A. MONABATI, N. TANIDEH, and R. KHAJEH, “COMPARISON OF EARLY VERSUS LATE POST-OPERATIVE ENTERAL FEEDING AFTER COLON ANASTOMOSIS IN RABBITS,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 3, no. 1, pp. 31–36, 2004, [Online]. Available: https://sid.ir/paper/105794/en

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