THE EFFECT OF HIGH DOSE TESTOSTERONE ENANTHATE ADMINISTRATION ON THYROID GLAND FUNCTION IN RAT

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ZARIFKAR A.A.; AI J.; JAZAYERI Z.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2004 | Volume:2 | Issue:2 Page(s): 1-10

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Title

THE EFFECT OF HIGH DOSE TESTOSTERONE ENANTHATE ADMINISTRATION ON THYROID GLAND FUNCTION IN RAT

Author(s)

ZARIFKAR A.A. | AI J. | JAZAYERI Z. | Issue Writer Certificate

Keywords

TESTOSTERONE ENANTHATEQ4

THYROID GLANDQ4

TRIIODOTHYRONINEQ3

THYROXINEQ3

THYROTROPIN (TSH)Q3

Abstract

Background: TESTOSTERONE ENANTHATE (TE) has important anabolic effects and is widely used by athletes as a stimulating drug for increasing muscle strength. Previous studies have shown that high doses of TE may have some effect on the secretion of metabolic hormones. The aim of this study was to evaluate the effect(s) of high dose TE on THYROID GLAND function. Materials and Methods: One hundred and twenty male Charles River rats (210-220g) were divided to five groups of 24: In group I, the control group, the rats did not have any operation or injection. In group II, the rats were gonadectomized and received TE (5 milligram per 100 gram of body weight, as weekly intraperitoneal injection). In group III, the gonadectomized rats only received a vehicle (olive oil). Group IV was comprized of sham- operated nongonadectomized rats that received the same dose of TE as in group II. In group V, sham-operated non-gonadectomised rats, only received a vehicle. In each group, blood samples were taken from eight rats after 20, 40 and 60 days. The serum levels of testosterone, T3, T4 and TSH were measured by ELISA. Results: Serum levels of T3 in groups II and IV that received TE, were significantly less than those in the control group (p<0.05). However, there were no significant differences between serum levels of T4 in the five groups. After 40 days, the serum TSH concentrations in groups II and IV were significantly lower than those in the control group (p<0.05). Conclusion: The results suggest that TE influences T3 and T4 metabolism in peripheral tissues and probably affects TSH and T4 secretions, centrally, through the hypothalamic- hypophysial-thyroid axis.

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APA: Copy

ZARIFKAR, A.A., AI, J., & JAZAYERI, Z.. (2004). THE EFFECT OF HIGH DOSE TESTOSTERONE ENANTHATE ADMINISTRATION ON THYROID GLAND FUNCTION IN RAT. JOURNAL OF MEDICAL RESEARCH (JMR), 2(2), 1-10. SID. https://sid.ir/paper/105801/en

Vancouver: Copy

ZARIFKAR A.A., AI J., JAZAYERI Z.. THE EFFECT OF HIGH DOSE TESTOSTERONE ENANTHATE ADMINISTRATION ON THYROID GLAND FUNCTION IN RAT. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2004;2(2):1-10. Available from: https://sid.ir/paper/105801/en

IEEE: Copy

A.A. ZARIFKAR, J. AI, and Z. JAZAYERI, “THE EFFECT OF HIGH DOSE TESTOSTERONE ENANTHATE ADMINISTRATION ON THYROID GLAND FUNCTION IN RAT,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 2, no. 2, pp. 1–10, 2004, [Online]. Available: https://sid.ir/paper/105801/en

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