LIVER ENZYME ASSESSMENT IN THALASSEMIA MAJOR PATIENTS WHO UNDERWENT BONE MARROW TRANSPLANTATION, SHIRAZ 2002

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KARIMI M.; MOSALANEZHAD LEYLI; ABDOLAHI FARD M.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2004 | Volume:2 | Issue:3 Page(s): 62-70

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Title

LIVER ENZYME ASSESSMENT IN THALASSEMIA MAJOR PATIENTS WHO UNDERWENT BONE MARROW TRANSPLANTATION, SHIRAZ 2002

Author(s)

KARIMI M. | MOSALANEZHAD LEYLI | ABDOLAHI FARD M. | Issue Writer Certificate

Keywords

THALASSEMIA MAJORQ3

LIVER FUNCTIONQ3

BONE MARROW TRANSPLANTIONQ4

Abstract

Background: Thalassemia is a common hereditary disease with a high prevalence rate in Iran. The most ideal treatment of THALASSEMIA MAJOR is bone marrow transplantation. The aim of this study was to assess the LIVER FUNCTION of THALASSEMIA MAJOR patients who underwent bone marrow transplantation. Patients and Methods: LIVER FUNCTION test and complete blood count were assessed during a 12-month period in 43 patients with THALASSEMIA MAJOR who had undergone bone marrow transplantation. Data were analyzed using t tests and analysis of variance. Results: The majority of cases were between 5 to 15 years with an equal sex distribution and had a hemoglobin level of less than 7 mg/dL with regular desferal injections. In most of the cases, desferal injection had started between the ages of one to four years. The age in which blood transfusion was initiated was under the age of one year. Most of the cases had iron deposition in the liver and negative serum hepatitis B surface antigen. In classes II and III, there was a statistically significant relationship between liver enzyme changes in pre and post-transplantation period (p<0.05). Increase in the level of liver enzymes in class II and III patients were also found (p<0.05). However, protein and albumin were within normal ranges. Total and direct bilirubin levels showed great variation but were within normal range. The hemoglobin, platelet and white blood cells decreased in early post-transplantation months then increased to reach a normal level. Conclusion: The results of this study showed that changes in the LIVER FUNCTION after bone marrow transplantation are directly related to LIVER FUNCTION before bone marrow transplantation. Unfortunately, if there is more iron deposition in the liver before transplantation, more liver damage will be unavoidable after bone marrow transplantation. Therefore, bone marrow transplantation as a treatment for THALASSEMIA MAJOR is not indicated in patients with end stage liver disease or in patients with class II or III LIVER FUNCTION unless concomitant bone marrow and liver transplantations can be performed.

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بررسی اثر بخشی بحث گروهی بر تصویر ذهنی نوجوانان (18-11 سال) تالاسمیک

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APA: Copy

KARIMI, M., MOSALANEZHAD, LEYLI, & ABDOLAHI FARD, M.. (2004). LIVER ENZYME ASSESSMENT IN THALASSEMIA MAJOR PATIENTS WHO UNDERWENT BONE MARROW TRANSPLANTATION, SHIRAZ 2002. JOURNAL OF MEDICAL RESEARCH (JMR), 2(3), 62-70. SID. https://sid.ir/paper/105808/en

Vancouver: Copy

KARIMI M., MOSALANEZHAD LEYLI, ABDOLAHI FARD M.. LIVER ENZYME ASSESSMENT IN THALASSEMIA MAJOR PATIENTS WHO UNDERWENT BONE MARROW TRANSPLANTATION, SHIRAZ 2002. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2004;2(3):62-70. Available from: https://sid.ir/paper/105808/en

IEEE: Copy

M. KARIMI, LEYLI MOSALANEZHAD, and M. ABDOLAHI FARD, “LIVER ENZYME ASSESSMENT IN THALASSEMIA MAJOR PATIENTS WHO UNDERWENT BONE MARROW TRANSPLANTATION, SHIRAZ 2002,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 2, no. 3, pp. 62–70, 2004, [Online]. Available: https://sid.ir/paper/105808/en

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