THE VALUE OF DETERMINING ANTIPATERNAL LEUKOCYTE ANTIBODIES IN THE DIAGNOSIS OF ALLOIMMUNE FACTORS IN RECURRENT ABORTION

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ZOU ALGHADRI J.; TAVANA Z.; GHADERI A.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2004 | Volume:2 | Issue:3 Page(s): 54-61

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Title

THE VALUE OF DETERMINING ANTIPATERNAL LEUKOCYTE ANTIBODIES IN THE DIAGNOSIS OF ALLOIMMUNE FACTORS IN RECURRENT ABORTION

Author(s)

ZOU ALGHADRI J. | TAVANA Z. | GHADERI A. | Issue Writer Certificate

Keywords

ANTIPATERNAL LEUKOCYTE ANTIBODYQ2

RECURRENT ABORTIONQ4

ALLOIMMUNITYQ4

Abstract

Background: Habitual abortion is defined as the occurrence of three or more consecutive pregnancy losses before the twentieth week of gestation. This is a challengeable clinical issue, as no cause can be found for abortion in over 50% of patients. There is increasing evidence to support an alloimmune mechanism in the unexplained group. It has been stated that the absence of maternal antibodies against the paternal leukocyte antigen (APLA) presented by the fetus causes abortion in this group. The objective of this study was to determine the value of APLA in the diagnosis of immunological causes of unexplained habitual abortion. Patients and Methods: One-hundred-thirty women with primary habitual abortion who had referred to Motahari Clinic, Shiraz, were enrolled in the study. In patients with nonspecific causes for abortion (unexplained abortion) white blood cell cross match was done for determination of APLA. Also, in the control group (women with at least one term pregnancy who had referred for kidney donation), APLA was determined. Immunization with paternal leukocytes was done for patients with negative APLA in several steps. Results: In fifty (38.5%) women out of 130 cases with habitual abortion, no recognized cause was found. APLA was positive in 8% and 20% in the case and control groups, respectively. There was no statistical difference between the two groups. Overall, 88% of the patients with negative APLA were immunized with paternal leukocytes. Conclusion: A negative APLA test does not correlate with the immunological basis of unexplained habitual abortion.

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APA: Copy

ZOU ALGHADRI, J., TAVANA, Z., & GHADERI, A.. (2004). THE VALUE OF DETERMINING ANTIPATERNAL LEUKOCYTE ANTIBODIES IN THE DIAGNOSIS OF ALLOIMMUNE FACTORS IN RECURRENT ABORTION. JOURNAL OF MEDICAL RESEARCH (JMR), 2(3), 54-61. SID. https://sid.ir/paper/105809/en

Vancouver: Copy

ZOU ALGHADRI J., TAVANA Z., GHADERI A.. THE VALUE OF DETERMINING ANTIPATERNAL LEUKOCYTE ANTIBODIES IN THE DIAGNOSIS OF ALLOIMMUNE FACTORS IN RECURRENT ABORTION. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2004;2(3):54-61. Available from: https://sid.ir/paper/105809/en

IEEE: Copy

J. ZOU ALGHADRI, Z. TAVANA, and A. GHADERI, “THE VALUE OF DETERMINING ANTIPATERNAL LEUKOCYTE ANTIBODIES IN THE DIAGNOSIS OF ALLOIMMUNE FACTORS IN RECURRENT ABORTION,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 2, no. 3, pp. 54–61, 2004, [Online]. Available: https://sid.ir/paper/105809/en

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