PROGNOSTIC SIGNIFICANCE OF DNA CONTENT ANALYSIS IN SOFT TISSUE TUMORS

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TORABINEZHAD S.; KARAMI B.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2004 | Volume:2 | Issue:3 Page(s): 1-14

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Title

PROGNOSTIC SIGNIFICANCE OF DNA CONTENT ANALYSIS IN SOFT TISSUE TUMORS

Author(s)

TORABINEZHAD S. | KARAMI B. | Issue Writer Certificate

Keywords

SOFT TISSUE NEOPLASMQ4

SARCOMAQ3

FLOW CYTOMETRYQ3

PLOIDYQ4

S-PHASE FRACTIONQ4

GRADINGQ4

Abstract

Background: Soft tissue SARCOMAs are aggressive tumors with a relatively high mortality rate in comparison to carcinomas. GRADING is one of the most important determinators of biological behavior in these tumors. The aim of the present study was to compare the PLOIDY status and DNA content in soft tissue SARCOMAs versus benign soft tissue tumors and to determine the value of the objective method of GRADING in soft tissue SARCOMAs. Materials and Methods: Fifty–two soft tissue tumors, including thirty-four SARCOMAs and eighteen benign tumors as well as non-neoplastic lesions were collected. Histologic diagnoses were reviewed and the GRADING system (FNCLCC GRADING system) was reassessed for SARCOMAs. DNA contents of all cases were determined on paraffin-embedded tissue blocks by FLOW CYTOMETRY. DNAs were analyzed for PLOIDY status, S-PHASE FRACTION and GRADING. Results: Twelve cases among 18 benign soft tissue lesions were DNA diploid. One lymphangioma, one intramuscular hemangioma and one atypical benign fibrous histiocytoma exhibited hyperdiploidy while two granular cell tumors and one paraganglioma were tetraploid. The mean of S-PHASE FRACTION for benign diploid and aneuploid lesions was 23.9 and 41.5 percent, respectively. About one-third of the SARCOMAs were diploid and two-third exhibited aneuploidy. The mean of S-PHASE FRACTION for diploid SARCOMAs was 23 percent, as compared to 42 percent in aneuploid SARCOMAs (with a cut–off value of 20). No relationship was found between aneuploidy and GRADING or PLOIDY status and tumor differentiation. The mean of S-PHASE FRACTION significantly correlated with higher grades (p=0.001). Conclusion: Evaluation of DNA PLOIDY status is an unreliable method for predicting prognosis in soft tissue SARCOMAs. Nevertheless, S-PHASE FRACTION determination in soft tissue tumors may be considered as a prognostically valuable adjuvant.

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APA: Copy

TORABINEZHAD, S., & KARAMI, B.. (2004). PROGNOSTIC SIGNIFICANCE OF DNA CONTENT ANALYSIS IN SOFT TISSUE TUMORS. JOURNAL OF MEDICAL RESEARCH (JMR), 2(3), 1-14. SID. https://sid.ir/paper/105810/en

Vancouver: Copy

TORABINEZHAD S., KARAMI B.. PROGNOSTIC SIGNIFICANCE OF DNA CONTENT ANALYSIS IN SOFT TISSUE TUMORS. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2004;2(3):1-14. Available from: https://sid.ir/paper/105810/en

IEEE: Copy

S. TORABINEZHAD, and B. KARAMI, “PROGNOSTIC SIGNIFICANCE OF DNA CONTENT ANALYSIS IN SOFT TISSUE TUMORS,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 2, no. 3, pp. 1–14, 2004, [Online]. Available: https://sid.ir/paper/105810/en

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