Investigating the Effect of Longitudinal Biomarkers on Hemodialysis Elderly Survival: A Single Central Study

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Asadollahi Dehkordi Behnoush; BIGLARIAN AKBAR; OSSAREH SHAHRZAD; VAHEDI MOHSEN

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Journal Paper

Paper Information

Journal: Salmand: Iranian Journal of Ageing Year:2022 | Volume:17 | Issue:2 Page(s): 202-217

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Information Journal Paper

Title

Investigating the Effect of Longitudinal Biomarkers on Hemodialysis Elderly Survival: A Single Central Study

Author(s)

Asadollahi Dehkordi Behnoush | BIGLARIAN AKBAR | OSSAREH SHAHRZAD | VAHEDI MOHSEN | Issue Writer Certificate

Keywords

Multivariate longitudinal data

Hemodialysis

Survival models

Two-stage models

Creatinine

Calsium

Phosphorus

PTH

Elderly

Abstract

Objectives: This study aims to identify the factors affecting the survival of Hemodialysis patients using a two-stage survival/multivariate longitudinal modelling. Methods & Materials: The is a retrospective cohort study on 395 patients aged > 60 years who underwent Hemodialysis in Hasheminejad Hospital in Tehran, Iran. Data were collected over a 15-year period from 2004 to 2019. Phosphate, calcium, parathormone and Creatinine variables were considered as longitu‐,dinal variables and mortality as a survival response. The two-stage survival and multivariate longitudinal modeling for long-term Hemodialysis patients were fitted and the results: were compared according to theirs likelihood function. Data analysis was performed in RStudio v. 3. 4. 3 and SAS v. 4. 9 applications. The significance level was set at 0. 05. Results The mean age of patients was 70. 41±, 6. 11 years. Of 395 patients, 249(63%) were male. Based on the log-likelihood function, the communication structure of the cumulative effect of longitudinal biomark‐,ers and survival data was selected. Assuming that other variables were constant, the significance of values for mobility impairment, calcium level and parathormone level indicated that these variables were good predictors of the occurrence of death in Hemodialysis patients over time. By each unit increase in each variables of mobility impairment, calcium level, and parathormone level, the risk of death increased by 1. 391, 0. 927, and 0. 967, respectively. Conclusion: By using a two-stage modelling, the variables of mobility impairment, calcium level and para‐,thormone are found as factors affecting the risk of death in Hemodialysis patients. Therefore, therapists should focus on changing health behaviors of these patients in consuming calcium and parathormone.

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APA: Copy

Asadollahi Dehkordi, Behnoush, BIGLARIAN, AKBAR, OSSAREH, SHAHRZAD, & VAHEDI, MOHSEN. (2022). Investigating the Effect of Longitudinal Biomarkers on Hemodialysis Elderly Survival: A Single Central Study. IRANIAN JOURNAL OF AGEING, 17(2 ), 202-217. SID. https://sid.ir/paper/1066909/en

Vancouver: Copy

Asadollahi Dehkordi Behnoush, BIGLARIAN AKBAR, OSSAREH SHAHRZAD, VAHEDI MOHSEN. Investigating the Effect of Longitudinal Biomarkers on Hemodialysis Elderly Survival: A Single Central Study. IRANIAN JOURNAL OF AGEING[Internet]. 2022;17(2 ):202-217. Available from: https://sid.ir/paper/1066909/en

IEEE: Copy

Behnoush Asadollahi Dehkordi, AKBAR BIGLARIAN, SHAHRZAD OSSAREH, and MOHSEN VAHEDI, “Investigating the Effect of Longitudinal Biomarkers on Hemodialysis Elderly Survival: A Single Central Study,” IRANIAN JOURNAL OF AGEING, vol. 17, no. 2 , pp. 202–217, 2022, [Online]. Available: https://sid.ir/paper/1066909/en

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