miR-802-5p is a key regulator in diabetic kidney disease (Short CommuniCation)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Kiyanpour Farnoush; ABEDI MARYAM; GHEISARI YOUSOF

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2023 | Volume:28 | Issue:- Page(s): 0-0

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

miR-802-5p is a key regulator in diabetic kidney disease (Short CommuniCation)

Author(s)

Kiyanpour Farnoush | ABEDI MARYAM | GHEISARI YOUSOF | Issue Writer Certificate

Keywords

Diabetic nephropathy

microRNAs

systems biology

Abstract

Background: Diabetic kidney disease has substantial burden and limited therapeutic options. An inadequate understanding of the complex gene regulatory circuits underlying this disorder contributes to the insufficiency of current treatment strategies. microRNAs (miRNAs) play a crucial role as regulators of functionally related gene networks. Previously, mmu-mir-802-5p was identified as the sole dysregulated miRNA in both the kidney cortex and medulla of diabetic mice. This study aims to investigate the role of miR-802-5p in diabetic kidney disease. Materials and Methods: The validated and predicted targets of miR-802-5p were identified using miRTarBase and TargetScan databases, respectively. The functional role of this miRNA was inferred using gene ontology enrichment analysis. The expression of miR-802-5p and its selected targets were assessed by qPCR. The expression of the angiotensin receptor (Agtr1a) was measured by ELISA. Results: miR-802-5p exhibited dysregulation in both the kidney cortex and medulla of diabetic mice, with two-and four-fold over-expressions, respectively. Functional enrichment analysis of the validated and predicted targets of miR-802-5p revealed its involvement in the renin-angiotensin pathway, inflammation, and kidney development. Differential expression was observed in the Pten transcript and Agtr1a protein among the examined gene targets. Conclusion: These findings suggest that miR-802-5p is a critical regulator of Diabetic nephropathy in the cortex and medulla compartments, contributing to disease pathogenesis through the reninangiotensin axis and inflammatory pathways.

Cites

No record.

References

Cite

APA: Copy

Kiyanpour, Farnoush, ABEDI, MARYAM, & GHEISARI, YOUSOF. (2023). miR-802-5p is a key regulator in diabetic kidney disease (Short CommuniCation). JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 28(-), 0-0. SID. https://sid.ir/paper/1067012/en

Vancouver: Copy

Kiyanpour Farnoush, ABEDI MARYAM, GHEISARI YOUSOF. miR-802-5p is a key regulator in diabetic kidney disease (Short CommuniCation). JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2023;28(-):0-0. Available from: https://sid.ir/paper/1067012/en

IEEE: Copy

Farnoush Kiyanpour, MARYAM ABEDI, and YOUSOF GHEISARI, “miR-802-5p is a key regulator in diabetic kidney disease (Short CommuniCation),” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 28, no. -, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1067012/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops