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Information Journal Paper

Title

Comparison of Biochemical and Hematological Parameters Among COVID-19 Patients With and Without Vaccination in a Tertiary Care Hospital: A Retrospective Study

Pages

  45-52

Abstract

 Background: The availability of the COVID-19 Vaccine during the pandemic has changed the disease course in the entire world. The current study aimed to compare various hematological parameters among COVID-19 patients with and without vaccination. Methods: The present retrospective study included 26 vaccinated and 26 non-vaccinated COVID-19 patients. Various clinical and biochemical parameters of RT-PCR-positive patients were collected. The values are expressed in Mean±, SD or median values IQR. Mann-Whitney U test was used for comparison between the groups. Results: Among the vaccinated individuals, 17 cases (65. 4%) were asymptomatic, one patient (3. 8%) had moderate, eight cases (30. 8%) had mild COVID-19 infection and all 26 patients were completely recovered. Among non-vaccinated COVID-19 patients, 25 cases (96. 2%) had severe, one case (3. 8%) had moderate COVID-19, and 16 patients (61. 5%) recovered but ten cases succumbed to COVID-19. There were statistically significant differences in SpO2, total leucocyte count, and differential counts of neutrophils, lymphocytes, eosinophils, monocytes, and basophils between vaccinated and non-vaccinated patients (P<0. 001). The neutrophil/ lymphocyte ratio was found to be at a higher level (P<0. 01) among non-vaccinated patients [10. 9(4. 28-23. 63)] compared to vaccinated [1. 55(1. 09-2. 28)]. The blood urea, total and direct bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and Inflammatory markers, like C-reactive protein (CRP), D-dimer, ferritin, and lactate dehydrogenase (LDH) were highly elevated in non-vaccinated patients (P<0. 001). Moreover, lower values of total protein, serum albumin, and albumin and globulin (A/G) ratio were noted in the non-vaccinated compared to vaccinated individuals (P<0. 001). Conclusion: Vaccinated patients had milder disease with fewer derangements of hematological parameters compared to non-vaccinated patients. It can be concluded that Vaccine has played a vital role during the COVID-19 pandemic in reducing mortality.

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    Cite

    APA: Copy

    Petimani, Mahalaxmi S., Adake, Prabhakar, Pavithra, H., & Kaladharan, Drisya. (2023). Comparison of Biochemical and Hematological Parameters Among COVID-19 Patients With and Without Vaccination in a Tertiary Care Hospital: A Retrospective Study. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 9(1), 45-52. SID. https://sid.ir/paper/1068516/en

    Vancouver: Copy

    Petimani Mahalaxmi S., Adake Prabhakar, Pavithra H., Kaladharan Drisya. Comparison of Biochemical and Hematological Parameters Among COVID-19 Patients With and Without Vaccination in a Tertiary Care Hospital: A Retrospective Study. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2023;9(1):45-52. Available from: https://sid.ir/paper/1068516/en

    IEEE: Copy

    Mahalaxmi S. Petimani, Prabhakar Adake, H. Pavithra, and Drisya Kaladharan, “Comparison of Biochemical and Hematological Parameters Among COVID-19 Patients With and Without Vaccination in a Tertiary Care Hospital: A Retrospective Study,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 9, no. 1, pp. 45–52, 2023, [Online]. Available: https://sid.ir/paper/1068516/en

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