Study of Chlorpheniramine-induced Genotoxicity in Human Peripheral Blood Lymphocytes

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ZAMANI EHSAN; Mahboubi Saba; Evazalipour Mehdi

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Journal Paper

Paper Information

Journal: Pharmaceutical and Biomedical Research Year:2023 | Volume:9 | Issue:1 Page(s): 63-72

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Information Journal Paper

Title

Study of Chlorpheniramine-induced Genotoxicity in Human Peripheral Blood Lymphocytes

Author(s)

ZAMANI EHSAN | Mahboubi Saba | Evazalipour Mehdi | Issue Writer Certificate

Keywords

Chlorpheniramine

Oxidative stress

Genotoxicity

Lymphocytes

Comet assay

Abstract

Background: Chlorpheniramine is an H1 receptor inverse agonist, which belongs to the first-generation class. It is generally regarded as a strong antihistamine with a wide variety of indications in allergic and non-allergic diseases. The extensive consumption of Chlorpheniramine might culminate in less evident adverse effects, such as Genotoxicity. Objectives: In this study, we attempted to assess the possible potential of Chlorpheniramine in inducing Genotoxicity. Methods: Human Lymphocytes were separated into groups as follows: control group (Phosphate Buffered saline), Chlorpheniramine group (0. 1, 0. 5, 0. 75, 1. 5 mM), and Positive control group (cisplatin 0. 4 μ, g/mL). After 24 hours of incubation, we conducted an alkaline Comet assay to evaluate the DNA damage. Also, Oxidative stress damage was evaluated by the levels of lipid peroxidation and glutathione oxidation. Results: Significant increases were observed in DNA percentage in tail and tail moment at high concentration (1. 5mM, P<0. 05). Likewise, at the same concentration, the MDA levels increased significantly in addition to the significant depletion in the level of glutathione. Conclusion: High concentration of Chlorpheniramine significantly induced Genotoxicity in human Lymphocytes. In addition, we showed that Oxidative stress was one of the mechanisms elaborated in Chlorpheniramine Genotoxicity at high concentrations.

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References

Acrylamide Induced Oxidative Cellular Senescence in Embryonic Fibroblast Cell Line (NIH 3T3): A Protection by Carvacrol

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APA: Copy

ZAMANI, EHSAN, Mahboubi, Saba, & Evazalipour, Mehdi. (2023). Study of Chlorpheniramine-induced Genotoxicity in Human Peripheral Blood Lymphocytes. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 9(1), 63-72. SID. https://sid.ir/paper/1068519/en

Vancouver: Copy

ZAMANI EHSAN, Mahboubi Saba, Evazalipour Mehdi. Study of Chlorpheniramine-induced Genotoxicity in Human Peripheral Blood Lymphocytes. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2023;9(1):63-72. Available from: https://sid.ir/paper/1068519/en

IEEE: Copy

EHSAN ZAMANI, Saba Mahboubi, and Mehdi Evazalipour, “Study of Chlorpheniramine-induced Genotoxicity in Human Peripheral Blood Lymphocytes,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 9, no. 1, pp. 63–72, 2023, [Online]. Available: https://sid.ir/paper/1068519/en

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