Screening of phytochemicals, toxicities, and activities of three Dillenia species

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Siripiyasing Pornnarong; Silawong Kittiya; Thooptianrat Tikumporn; Sudmoon Runglawan; Babayan Nelly; Khondkaryan Lusine; Apresyan Lilit; Tanee Tawatchai; Chaveerach Arunrat

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Journal: JOURNAL OF HERBMED PHARMACOLOGY Year:2022 | Volume:11 | Issue:3 Page(s): 339-347

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Title

Screening of phytochemicals, toxicities, and activities of three Dillenia species

Author(s)

Keywords

-Sitosterol

Comet assay

Oleamide

Toxicity

Abstract

Introduction: Plants containing β,-Sitosterol and Oleamide are important for various diseases. So, Dillenia indica, D. obovata, and D. pentagyna were investigated for phytochemicals, cytoToxicity and genoToxicity levels on peripheral blood mononuclear cells (PBMCs) and Hela cells. The protective effect of D. pentagyna extract on a HepG2 cell line was also investigated. Methods: Gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) were used for phytochemical analysis. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) tetrazolium reduction (MTT) and Comet assays were performed for Toxicity testing and protective effects against DNA oxidative damage. Results: The major components were Oleamide and β,-Sitosterol at 38. 464-58. 247% and 5. 585-6. 887% with concentration and quantity of β,-Sitosterol at 0. 2-0. 37 mg/mL and 0. 42-0. 964 mg/g leaf. The D. indica, D. obovata, and D. pentagyna toxicities on PBMCs showed IC50 values at >430, >430, and 350 μ, g/mL respectively, with no significant DNA damage (P > 0. 05) compared to the negative control group. All plant extracts showed toxic activity on Hela cell with IC50 values at <0. 43 μ, g/mL and induced significant DNA damage (P < 0. 05) compared to the negative control group. Conversely, the activity of the D. pentagyna extract indicated low cytotoxic activity against HepG2 (IC50>430 μ, g/mL), no significant (P > 0. 05) DNA damage induction, significantly (P < 0. 05) decreased DNA damage level, and tremendous antioxidant effect. Additionally, a combined mixture of all plants in an equal proportion revealed no IC50 value and insignificant DNA damage. Conclusion: All the studied species contained Oleamide and β,-Sitosterol, with Toxicity on Hela cells without Toxicity on PBMC. The D. pentagyna species showed high antioxidant effects and no Toxicity on HepG2.

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APA: Copy

Siripiyasing, Pornnarong, Silawong, Kittiya, Thooptianrat, Tikumporn, Sudmoon, Runglawan, Babayan, Nelly, Khondkaryan, Lusine, Apresyan, Lilit, Tanee, Tawatchai, & Chaveerach, Arunrat. (2022). Screening of phytochemicals, toxicities, and activities of three Dillenia species. JOURNAL OF HERBMED PHARMACOLOGY, 11(3), 339-347. SID. https://sid.ir/paper/1074139/en

Vancouver: Copy

Siripiyasing Pornnarong, Silawong Kittiya, Thooptianrat Tikumporn, Sudmoon Runglawan, Babayan Nelly, Khondkaryan Lusine, Apresyan Lilit, Tanee Tawatchai, Chaveerach Arunrat. Screening of phytochemicals, toxicities, and activities of three Dillenia species. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2022;11(3):339-347. Available from: https://sid.ir/paper/1074139/en

IEEE: Copy

Pornnarong Siripiyasing, Kittiya Silawong, Tikumporn Thooptianrat, Runglawan Sudmoon, Nelly Babayan, Lusine Khondkaryan, Lilit Apresyan, Tawatchai Tanee, and Arunrat Chaveerach, “Screening of phytochemicals, toxicities, and activities of three Dillenia species,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 11, no. 3, pp. 339–347, 2022, [Online]. Available: https://sid.ir/paper/1074139/en

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