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Information Journal Paper

Title

Antioxidant and anti-inflammatory activities of Ganoderma resinaceum (Boud) fruiting bodies extracts

Pages

  348-359

Abstract

 Introduction: Ganoderma resinaceum is used to treat oxidative and inflammatory-related diseases such as cardiovascular and liver diseases. Thus, this study aimed to evaluate the Antioxidant and anti-inflammatory activities of different extracts from G. resinaceum fruiting bodies. Methods: Aqueous crude (GRT), mycelial (MYC), exopolysaccharide (EPS I, EPS II) and water-soluble polysaccharide-rich (GRP I and GRP II) extracts of G. resinaceum were assessed for their free radical scavenging and metal chelating ions assays. The in vitro anti-inflammatory activity was evaluated by stabilization of erythrocytes’,membranes and protein denaturation assays. For the in vivo study, paw oedema was induced by administration of κ,-carrageenan (0. 1 mL,1%) to male Wistar rats aged 4 to 6 weeks. Animals were pre-treated with G. resinaceum extracts (125 mg/kg) and diclofenac sodium (20 mg/kg). Inflammatory cytokine and chemokine levels were determined, and histological analysis of paw tissue was performed. Results: G. resinaceum polysaccharide-rich extracts (GRP I and GRP II) showed the best bioactivities. They scavenged DPPH (1, 1-diphenyl-2-picrylhydrazyl, ABTS (2, 2-azino-bis-3-ethylbenzylthiazoline-6-sulfonic acid, and NO (nitric oxide) radicals, and chelated ferrous ions, stabilized murine erythrocyte membranes, and inhibited protein denaturation. At 125 mg/kg, GRP I and GRP II restored the microarchitecture with a weak infiltration of immune cells in the subcutaneous tissues. Moreover, they decreased the overproduction of proinflammatory Cytokines growth colony-stimulating factor (G-CSF), interferon gamma (IFNγ, ), tumour necrosis factor alpha (TNFα, ), Chemokines (eotaxin, fractalkine) and increased the levels of anti-inflammatory Cytokines (IL-10, IL-12p70). Conclusion: G. resinaceum polysaccharide extracts could be potent Antioxidant and anti-inflammatory agents.

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    APA: Copy

    Mediesse, Francine Kengne, Natia Sombes, Annette Yannuvie, Mfopa, Adamou, & Boudjeko, Thaddee. (2022). Antioxidant and anti-inflammatory activities of Ganoderma resinaceum (Boud) fruiting bodies extracts. JOURNAL OF HERBMED PHARMACOLOGY, 11(3), 348-359. SID. https://sid.ir/paper/1074260/en

    Vancouver: Copy

    Mediesse Francine Kengne, Natia Sombes Annette Yannuvie, Mfopa Adamou, Boudjeko Thaddee. Antioxidant and anti-inflammatory activities of Ganoderma resinaceum (Boud) fruiting bodies extracts. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2022;11(3):348-359. Available from: https://sid.ir/paper/1074260/en

    IEEE: Copy

    Francine Kengne Mediesse, Annette Yannuvie Natia Sombes, Adamou Mfopa, and Thaddee Boudjeko, “Antioxidant and anti-inflammatory activities of Ganoderma resinaceum (Boud) fruiting bodies extracts,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 11, no. 3, pp. 348–359, 2022, [Online]. Available: https://sid.ir/paper/1074260/en

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