The Effect of an 8-Week Resistance Training on ActRII? in Fast-and Slow-twitch Skeletal Muscles and Plasma Levels of GDF8, GDF11 and GASP-1 in Old Male Rats

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MASOUDIAN BEHNAM; AZAMIAN JAZI AKBAR; FARAMARZI MOHAMMAD; TALEBI ARDESHIR

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:25 | Issue:12 Page(s): 104-115

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Title

The Effect of an 8-Week Resistance Training on ActRII? in Fast-and Slow-twitch Skeletal Muscles and Plasma Levels of GDF8, GDF11 and GASP-1 in Old Male Rats

Author(s)

MASOUDIAN BEHNAM | AZAMIAN JAZI AKBAR | FARAMARZI MOHAMMAD | TALEBI ARDESHIR | Issue Writer Certificate

Keywords

Resistance TrainingQ1

ActRII??Q1

GDF11Q1

GDF8Q1

GASP-1Q1

OldQ1

Abstract

Background: Changing the concentration of growth factors and their receptors can affect sarcopenia (age-related muscular atrophy). The aim of this study was to determine the effects of an 8-week Resistance Training on ActRII?β in fast-and slow-twitch (FT & ST) skeletal muscles and plasma levels of GDF8, GDF11 and GASP1 in Old male rats. Methods: This study was conducted as a two-group experimental design with 14 Old male rats with age range 24 to 27 months and weighing 440± 24g. After the familiarization training, the rats were randomly divided into 2 groups of 7 control and training. The training protocol was included 8 weeks climbing from a 1 meter ladder. 5cc blood was taken from the left ventricle, 48 hours after the last session, for measurement of GDF8, GDF11 and GASP-1 by ELISA method. The soleus (SOL) muscle (ST) and flexor hallucis longus (FHL) muscle (FT) of rats were taken for measurement of ActRII?B by IHC method. Independent t-test was applied for statistical analysis of the data (p<0. 05). Results: Comparisons between groups showed that 8-week Resistance Training have a significant effects on GDF11 (P=0. 001), GDF8/GDF11 (P=0. 001), GDF8 (P=0. 027) and ActRII?β in SOL muscle (P=0. 013), but no between-groups differences were observed in GASP-1(P=0. 704) and ActRII?β in FHL muscle (P=0. 325). Conclusion: It seems that Resistance Training can reduce sarcopenia by favorable effects on growth factors and their receptors. However, more studies are needed in this regard.

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APA: Copy

MASOUDIAN, BEHNAM, AZAMIAN JAZI, AKBAR, FARAMARZI, MOHAMMAD, & TALEBI, ARDESHIR. (2019). The Effect of an 8-Week Resistance Training on ActRII? in Fast-and Slow-twitch Skeletal Muscles and Plasma Levels of GDF8, GDF11 and GASP-1 in Old Male Rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(12 ), 104-115. SID. https://sid.ir/paper/10745/en

Vancouver: Copy

MASOUDIAN BEHNAM, AZAMIAN JAZI AKBAR, FARAMARZI MOHAMMAD, TALEBI ARDESHIR. The Effect of an 8-Week Resistance Training on ActRII? in Fast-and Slow-twitch Skeletal Muscles and Plasma Levels of GDF8, GDF11 and GASP-1 in Old Male Rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;25(12 ):104-115. Available from: https://sid.ir/paper/10745/en

IEEE: Copy

BEHNAM MASOUDIAN, AKBAR AZAMIAN JAZI, MOHAMMAD FARAMARZI, and ARDESHIR TALEBI, “The Effect of an 8-Week Resistance Training on ActRII? in Fast-and Slow-twitch Skeletal Muscles and Plasma Levels of GDF8, GDF11 and GASP-1 in Old Male Rats,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 12 , pp. 104–115, 2019, [Online]. Available: https://sid.ir/paper/10745/en

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