Evaluation of Cytotoxicity of Endoseal MTA Sealer as a Root Canal Perforation Restorative Material on Gingival Fibroblasts Compared to Iranian ProRoot MTA and CEM by MTT test

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OMIDI SALMA; Dadgar Kosar; MESGARANI ABBAS; MOOSAZADEH MAHMOOD; Zaghi Hosseinzadeh Fatemeh

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Journal: Journal of Mashhad Dental School Year:2023 | Volume:46 | Issue:4 Page(s): 305-315

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Title

Evaluation of Cytotoxicity of Endoseal MTA Sealer as a Root Canal Perforation Restorative Material on Gingival Fibroblasts Compared to Iranian ProRoot MTA and CEM by MTT test

Author(s)

Keywords

CEM

Cytotoxicity

Endoseal MTA

MTT assay

Sealer

Abstract

Introduction: Root canal perforation is a reason for root canal treatment failures. Cytocompatibility is an essential feature of a perforation restorative material. This in vitro study aimed to evaluate the Cytotoxicity of Endoseal MTA Sealer as a root canal perforation restorative material on human gingival fibroblast cells in comparison to Iranian ProRoot MTA and CEM using tetrazolium-based colorimetric assay (MTT test). Materials and Methods: MTA, CEM, and Endoseal MTA were prepared and exposed (for 48 h) to cell culture media 72 h after setting. Human gingival fibroblasts were then cultivated and incubated for 24 h with different dilutions (1/2, 1/4, 1/8) of each Sealer extract. Cell viability was evaluated using the MTT test. The data were compared using the analysis of variance (ANOVA) followed by Tukey’, s post hoc test for multiple comparisons. P-values less than 0. 05 were considered statistically significant. Result: There was a significant association between CEM cell viability and Endoseal MTA as well as between MTA and CEM in 1/2 dilution. No significant difference was found in 1/4 and 1/8 dilusions between the percentage of cell viability of different Sealers. Conclusion: Based on the results of this study, although Endoseal MTA Sealer is more toxic than CEM in ½,dilution, it has higher biocompatibility compared to MTA and can be considered as a perforation restorative material in terms of other favorable qualities.

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APA: Copy

OMIDI, SALMA, Dadgar, Kosar, MESGARANI, ABBAS, MOOSAZADEH, MAHMOOD, & Zaghi Hosseinzadeh, Fatemeh. (2023). Evaluation of Cytotoxicity of Endoseal MTA Sealer as a Root Canal Perforation Restorative Material on Gingival Fibroblasts Compared to Iranian ProRoot MTA and CEM by MTT test. JOURNAL OF MASHHAD DENTAL SCHOOL, 46(4 ), 305-315. SID. https://sid.ir/paper/1074856/en

Vancouver: Copy

OMIDI SALMA, Dadgar Kosar, MESGARANI ABBAS, MOOSAZADEH MAHMOOD, Zaghi Hosseinzadeh Fatemeh. Evaluation of Cytotoxicity of Endoseal MTA Sealer as a Root Canal Perforation Restorative Material on Gingival Fibroblasts Compared to Iranian ProRoot MTA and CEM by MTT test. JOURNAL OF MASHHAD DENTAL SCHOOL[Internet]. 2023;46(4 ):305-315. Available from: https://sid.ir/paper/1074856/en

IEEE: Copy

SALMA OMIDI, Kosar Dadgar, ABBAS MESGARANI, MAHMOOD MOOSAZADEH, and Fatemeh Zaghi Hosseinzadeh, “Evaluation of Cytotoxicity of Endoseal MTA Sealer as a Root Canal Perforation Restorative Material on Gingival Fibroblasts Compared to Iranian ProRoot MTA and CEM by MTT test,” JOURNAL OF MASHHAD DENTAL SCHOOL, vol. 46, no. 4 , pp. 305–315, 2023, [Online]. Available: https://sid.ir/paper/1074856/en

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