Investigating the effect of MAP2K1 gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL)

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Hosseini Parastoo; RAHIMI FOROUSHANI ABBAS; Marjani Arezoo; TAVAKOLI MAHNAZ; Amiri Abdollah; Bahavar Atefeh; Mozhgani Sayed Hamidreza; NOROUZI MEHDI

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Journal: Iranian Journal of Microbiology Year:2023 | Volume:15 | Issue:3 Page(s): 475-481

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Title

Investigating the effect of MAP2K1 gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL)

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Keywords

Human T-lymphotropic virus type 1

HTLV-I-associated myelopathy

Tropical spastic paraparesis

Adult T-cell leukemia/lymphoma

Mitogen-activated protein kinase kinase 1

MAP kinase/ERK kinase

Abstract

Background and Objectives: HTLV-1 is responsible for two important diseases, HAM/TSP and ATLL. Approximately 10 to 20 million people are infected with HTLV-1 worldwide. Identifying altered genes in different cancers is crucial for finding potential treatment strategies. One of the proteins of the RAS/MAPK signaling pathway is MEK1, which is made from the MAP2K1 gene. The effects of the MAP2K1 gene on the MAPK signaling pathway are not yet fully elucidated. The current study aims to determine the MAP2K1 gene mutations and the level of MAP2K1 gene expression in ATLL patients compared to healthy individuals. Materials and Methods: Ten ATLL and 10 healthy control individuals were investigated in this study. We used ELISA test to screen anti-HTLV-I antibodies and PCR for confirmation of infection. Then, we extracted total RNA from fresh whole blood, and cDNA was synthesized. The expression levels of the MAP2K1 gene were examined by qRT-PCR, and to check possible mutations in the MAP2K1 gene,all samples were sequenced and analyzed by BioEdite Software. Results: MAP2K1 gene expression in the ATLL group was significantly higher than in the healthy control (P=0. 001). The mutational sequencing analysis showed nucleotide 212 (S→, R) change and identification mutations at different nucleotides that were entirely different from the nucleotide mutations defined in the UniProt database. Conclusion: These results could be a perspective in the prevention, prognosis, and targeted treatment of diseases in which the MAP2K1 gene plays a vital role.

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APA: Copy

Hosseini, Parastoo, RAHIMI FOROUSHANI, ABBAS, Marjani, Arezoo, TAVAKOLI, MAHNAZ, Amiri, Abdollah, Bahavar, Atefeh, Mozhgani, Sayed Hamidreza, & NOROUZI, MEHDI. (2023). Investigating the effect of MAP2K1 gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL). IRANIAN JOURNAL OF MICROBIOLOGY, 15(3), 475-481. SID. https://sid.ir/paper/1075515/en

Vancouver: Copy

Hosseini Parastoo, RAHIMI FOROUSHANI ABBAS, Marjani Arezoo, TAVAKOLI MAHNAZ, Amiri Abdollah, Bahavar Atefeh, Mozhgani Sayed Hamidreza, NOROUZI MEHDI. Investigating the effect of MAP2K1 gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL). IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2023;15(3):475-481. Available from: https://sid.ir/paper/1075515/en

IEEE: Copy

Parastoo Hosseini, ABBAS RAHIMI FOROUSHANI, Arezoo Marjani, MAHNAZ TAVAKOLI, Abdollah Amiri, Atefeh Bahavar, Sayed Hamidreza Mozhgani, and MEHDI NOROUZI, “Investigating the effect of MAP2K1 gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL),” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 15, no. 3, pp. 475–481, 2023, [Online]. Available: https://sid.ir/paper/1075515/en

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