THE TERATOGENIC EFFECTS OF RETINOIC ACID ON DEVELOPMENT OF LUMBOSACRAL OF NEURAL TUBE IN MOUSE

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ZIRAK A.; NOBACKT M.; MAHDIZADEH M.

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Journal: Razi Journal of Medical Sciences Year:2002 | Volume:8 | Issue:27 Page(s): 567-574

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Title

THE TERATOGENIC EFFECTS OF RETINOIC ACID ON DEVELOPMENT OF LUMBOSACRAL OF NEURAL TUBE IN MOUSE

Author(s)

ZIRAK A. | NOBACKT M. | MAHDIZADEH M. | Issue Writer Certificate

Keywords

MICEQ4

RETINOIC ACIDQ3

DEVELOPMENT OF NARAL TUBEQ4

Abstract

The present study has been investigated the teratogenic effects of RETINOIC ACID (RA) on development of neural tube in mice. We has studied the effects of teratogenic RETINOIC ACID on central nervous system development, because use of RA in drug-compositions and significance of this system . For teratogenic studies, after natural mating, pregnant MICE were divided into a intact group, control group and two experimental groups. On the 8th day of gestation, the pregnant MICE were given DMSO and RA in DMSO intraperitoneally in a dose of 40 or 60 mg/kg of body weight. Embryos were then isolated at 10th day of gestation and evaluated for macroscopic (apparent form, size and number of embryos), microscopic (neuroepithelial cells changes) and morphometric characteristics. The results show that RA cause craniofacial anomallies, decrease of size and the number of embryos of experimental groups which has a direct relation with the higher dose of this substance. Some cases show unfused neural folds in the dose of 40 mg/kg, but in the dose of 60 mg/kg this anomally is found in all the cases. Changes of neuroepithelial cells and disorganization enhance with the increase of dose. As a whole, doses of 40 and 60 mg/kg, cause disorganization and qualitative changes and also, delay the process of neural tube development .

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APA: Copy

ZIRAK, A., NOBACKT, M., & MAHDIZADEH, M.. (2002). THE TERATOGENIC EFFECTS OF RETINOIC ACID ON DEVELOPMENT OF LUMBOSACRAL OF NEURAL TUBE IN MOUSE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 8(27), 567-574. SID. https://sid.ir/paper/10767/en

Vancouver: Copy

ZIRAK A., NOBACKT M., MAHDIZADEH M.. THE TERATOGENIC EFFECTS OF RETINOIC ACID ON DEVELOPMENT OF LUMBOSACRAL OF NEURAL TUBE IN MOUSE. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2002;8(27):567-574. Available from: https://sid.ir/paper/10767/en

IEEE: Copy

A. ZIRAK, M. NOBACKT, and M. MAHDIZADEH, “THE TERATOGENIC EFFECTS OF RETINOIC ACID ON DEVELOPMENT OF LUMBOSACRAL OF NEURAL TUBE IN MOUSE,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 8, no. 27, pp. 567–574, 2002, [Online]. Available: https://sid.ir/paper/10767/en

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