EXPRESSION OF HLA CLASS-IA ON TUMOR CELL LINES AND THEIR SUSCEPTIBILITY TO NK CELL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAZAZI H.; FATEMINASAB F.D.; ENTEZAMI K.; SALEK MOGHADAM ALI REZA; SHAH GHASEMPOUR SHAPOUR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2002 | Volume:8 | Issue:27 Page(s): 541-548

Download Full-Text

Persian Verion

View:

758

Download:

Cites:

Information Journal Paper

Title

EXPRESSION OF HLA CLASS-IA ON TUMOR CELL LINES AND THEIR SUSCEPTIBILITY TO NK CELL

Author(s)

Keywords

HUMAN LEUKOCYTE ANTIGEN (HLA)Q4

NATURAL KILLER CELL (NK)Q4

TUMOR CELL LINE (TCL)Q4

MONOCLONAL ANTIBODY (M AB)Q3

MAJOR HISTO COMPATIBILITY COMPLEX (MHC)Q4

Abstract

Natural Killer cells (NKs), are considered an important first line of defence and were originally defined by their ability to kill certain tumor cells and virally infected cells. Our aim is to study expression of HLA class-Ia on tumor cell lines and their susceptibility of NK cells. In this study MDA-MB-468 tumor cell line (NCB1, C208) That derived from human breast adenocarcinoma, is selected as a model which expresses total alleles of HLA class I. To test HLA class I expression, we used the F.I.T.C conjugatedm Ab W6/32 which recognize assembled HLA-A, B and C locus products. Surface expression of HLA class I on the cell line are determined with single- color flowcytometry analysis. NK cells are obtained from PBL of healthy donors. Results of our study indicate that expression of HLA class I molecules on MDA- MB- 468 Tumor cell line are increased after IFN-γ Treatment. Cytolytic activity of NK cells have direct correlation (r =1) with up- regulation of HLA class I expression on the MDA- MB- 468 tumor cell line. Therefore, on the basis of this results, we suggest that, on the surface of NK cells may exsist activating receptors that recognize allogenic HLA class I molecules and/or non HLA class I ligand that is upregulated by IFN- & treatment, and cause lysis of target cells.

Cites

No record.

References

No record.

Cite

APA: Copy

BAZAZI, H., FATEMINASAB, F.D., ENTEZAMI, K., SALEK MOGHADAM, ALI REZA, & SHAH GHASEMPOUR, SHAPOUR. (2002). EXPRESSION OF HLA CLASS-IA ON TUMOR CELL LINES AND THEIR SUSCEPTIBILITY TO NK CELL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 8(27), 541-548. SID. https://sid.ir/paper/10774/en

Vancouver: Copy

BAZAZI H., FATEMINASAB F.D., ENTEZAMI K., SALEK MOGHADAM ALI REZA, SHAH GHASEMPOUR SHAPOUR. EXPRESSION OF HLA CLASS-IA ON TUMOR CELL LINES AND THEIR SUSCEPTIBILITY TO NK CELL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2002;8(27):541-548. Available from: https://sid.ir/paper/10774/en

IEEE: Copy

H. BAZAZI, F.D. FATEMINASAB, K. ENTEZAMI, ALI REZA SALEK MOGHADAM, and SHAPOUR SHAH GHASEMPOUR, “EXPRESSION OF HLA CLASS-IA ON TUMOR CELL LINES AND THEIR SUSCEPTIBILITY TO NK CELL,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 8, no. 27, pp. 541–548, 2002, [Online]. Available: https://sid.ir/paper/10774/en

Related Journal Papers