The effect of an aerobic exercise training with complementary probiotic supplementation on the gene expression of SIRT-1 and FNDC-5 in the left ventricle of diabetic male rats

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Samaie Seyedeh Somayeh; RAVASI ALI ASGHAR; CHOOBINEH SIROUS; DELFAN MARYAM

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Journal Paper

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Journal: Journal of Jiroft University of Medical Sciences Year:2022 | Volume:9 | Issue:2 Page(s): 999-1009

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Title

The effect of an aerobic exercise training with complementary probiotic supplementation on the gene expression of SIRT-1 and FNDC-5 in the left ventricle of diabetic male rats

Author(s)

Samaie Seyedeh Somayeh | RAVASI ALI ASGHAR | CHOOBINEH SIROUS | DELFAN MARYAM | Issue Writer Certificate

Keywords

Aerobic exercise training

SIRT-1

FNDC-5

Insulin resistance

Probiotic supplement

Abstract

Introduction: Aerobic exercise with Probiotic supplementation improves the antioxidant capacity in the left ventricle of diabetic patients by regulating gene expression. The purpose of this study was to investigate the effect of an Aerobic exercise training with complementary Probiotic supplementation on the gene expression of SIRT-1 and FNDC-5 in the left ventricle of streptozotocin-induced diabetic male rats. Materials and Methods: In this experimental research, 30 diabetic male laboratory rats were divided into five groups of six including, non-diabetic control (NC), diabetic control (DC), diabetic supplement (DS), diabetic training (DT), diabetic training supplement (DTS). Diabetes was induced in all groups except for non-diabetic control group by intraperitoneal injection of streptozotocin (STZ) at a dose of 60 mg per kilogram of body weight after 12 hours of overnight fasting. Real-time PCR technique was used to evaluate the gene expression of the SIRT-1and FNDC-5 and the comparison of groups was used by One way ANOVA at the alpha level of 0. 05. Results: SIRT-1 gene expression in DT and DTS groups compared to DC group, (p<0. 001) and (p<0. 01) respectively, and FNDC-5 gene expression in DT and DTS groups compared to DC group (p<0. 05) and (p<0. 001) significantly increased Conclusion: Aerobic exercise combined with Probiotic supplementation can possibly increase the antioxidant defense and improve diabetic cardiomyopathy by affecting the regulation of FNDC-5 gene expression in the left ventricle of diabetic rats.

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APA: Copy

Samaie, Seyedeh Somayeh, RAVASI, ALI ASGHAR, CHOOBINEH, SIROUS, & DELFAN, MARYAM. (2022). The effect of an aerobic exercise training with complementary probiotic supplementation on the gene expression of SIRT-1 and FNDC-5 in the left ventricle of diabetic male rats. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, 9(2 ), 999-1009. SID. https://sid.ir/paper/1077782/en

Vancouver: Copy

Samaie Seyedeh Somayeh, RAVASI ALI ASGHAR, CHOOBINEH SIROUS, DELFAN MARYAM. The effect of an aerobic exercise training with complementary probiotic supplementation on the gene expression of SIRT-1 and FNDC-5 in the left ventricle of diabetic male rats. JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;9(2 ):999-1009. Available from: https://sid.ir/paper/1077782/en

IEEE: Copy

Seyedeh Somayeh Samaie, ALI ASGHAR RAVASI, SIROUS CHOOBINEH, and MARYAM DELFAN, “The effect of an aerobic exercise training with complementary probiotic supplementation on the gene expression of SIRT-1 and FNDC-5 in the left ventricle of diabetic male rats,” JOURNAL OF JIROFT UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 2 , pp. 999–1009, 2022, [Online]. Available: https://sid.ir/paper/1077782/en

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