EVALUATION OF CTLA-4 EXON-1 +49A/G POLYMORPHISM IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS: A META ANALYSIS

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SHOJAA MAHDIEH; AGHAIE MEHRDAD; QORBANI MOSTAFA; KHASHAYAR PATRICIA; KESHTKAR ABBAS ALI; MOHEBI RAMIN

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Journal: Journal of Knowledge & Health in Basic Medical Sciences Year:2014 | Volume:9 | Issue:3 Page(s): 11-20

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Title

EVALUATION OF CTLA-4 EXON-1 +49A/G POLYMORPHISM IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS: A META ANALYSIS

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Keywords

SYSTEMIC LUPUS ERYTHEMATOUS (SLE)Q3

49AG POLYMORPHISMQ3

CTLA-4Q3

META-ANALYSISQ3

Abstract

Introduction: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of T-cell responses. The 49AG POLYMORPHISM of the CTLA-4 gene may be associated with systemic lupus erythematous (SLE) risk, but the results from previous published studies have been inconsistent. We carried out a META-ANALYSIS search to assess this association more precisely.Methods: A systematic search of six electronic databases (PubMed, Science Direct, OVID, Iran doc, Iran Medex and SID (Scientific Information Database) was performed for relevant articles published between 1978 and 2011. The odds ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of the association. We evaluated both fixed and random effect models, depending on the presence of between-study heterogeneity. The data were analyzed using STATA software.Results: A total of 15 independent studies on the CTLA-4 gene 49AG POLYMORPHISM and SLE, including 1705 cases and 2299 controls were used in the META-ANALYSIS. No significant association was found between 49AG POLYMORPHISM and SLE risk in the overall or subgroup analyses.Conclusion: This META-ANALYSIS showed no significant association between 49AG POLYMORPHISM and SLE susceptibility. Large-scale and well-designed case-control studies are suggested.

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APA: Copy

SHOJAA, MAHDIEH, AGHAIE, MEHRDAD, QORBANI, MOSTAFA, KHASHAYAR, PATRICIA, KESHTKAR, ABBAS ALI, & MOHEBI, RAMIN. (2014). EVALUATION OF CTLA-4 EXON-1 +49A/G POLYMORPHISM IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS: A META ANALYSIS. KNOWLEDGE AND HEALTH, 9(3), 11-20. SID. https://sid.ir/paper/107825/en

Vancouver: Copy

SHOJAA MAHDIEH, AGHAIE MEHRDAD, QORBANI MOSTAFA, KHASHAYAR PATRICIA, KESHTKAR ABBAS ALI, MOHEBI RAMIN. EVALUATION OF CTLA-4 EXON-1 +49A/G POLYMORPHISM IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS: A META ANALYSIS. KNOWLEDGE AND HEALTH[Internet]. 2014;9(3):11-20. Available from: https://sid.ir/paper/107825/en

IEEE: Copy

MAHDIEH SHOJAA, MEHRDAD AGHAIE, MOSTAFA QORBANI, PATRICIA KHASHAYAR, ABBAS ALI KESHTKAR, and RAMIN MOHEBI, “EVALUATION OF CTLA-4 EXON-1 +49A/G POLYMORPHISM IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS: A META ANALYSIS,” KNOWLEDGE AND HEALTH, vol. 9, no. 3, pp. 11–20, 2014, [Online]. Available: https://sid.ir/paper/107825/en

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