T790M and Acquired Resistance of Epidermal Growth Factor Receptor to Tyrosine Kinase Inhibitors in Patients with Lung Adenocarcinoma

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRTAVOOS MAHYARI HANIFEH; ABBASI DEZFOULI AZIZOLLAH; ESFAHANI MONFARED ZAHRA; KHOSRAVI ADNAN; SEIFI SHARAREH; SHEIKHY KAMBIZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TANAFFOS Year:2022 | Volume:21 | Issue:3 Page(s): 376-383

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

T790M and Acquired Resistance of Epidermal Growth Factor Receptor to Tyrosine Kinase Inhibitors in Patients with Lung Adenocarcinoma

Author(s)

Keywords

Epidermal growth factor receptor

T790M

Cell-free DNAs

Non–

small cell lung cancer

Abstract

Background: Activating mutations in the Epidermal growth factor receptor (EGFR) are initially responsive to tyrosine kinase inhibitors (TKIs), but responses to TKIs is not permanent and drug resistance eventually happens for almost all patients. Subsequent studies found different resistance mechanisms, among which (EGFR) T790M mutation is the most important mechanism of TKI treatment failure. Using cell-free DNA (cfDNA) is a new way for diagnosing resistance mutations in EGFR. The aim of present study is to determine cfDNAidentified recurrence mutation rate and their association with clinical outcome in lung Adenocarcinoma patients. Materials and Methods: Patients who were diagnosed with metastatic adenocarcinoma of the lung and acquired resistance to TKIs were enrolled. The incidence of T790M positivity, overall survival (OS) and median duration of TKI treatment before progression was calculated. Polymerase chain reaction (PCR) and sequencing were used to identify the T790M mutation in cfDNA. Results: The incidence of T790M mutations was higher in men, younger cases (<59 years), in patients with L858R primary mutation and never smokers although they were not significantly different (P-values= 041, 0. 316, 0. 316 and 0. 158, respectively). There was significant longer OS in the Del19 subgroup than the L858R subgroup (p = 0. 014). In multivariable analysis, significant longer OS was associated with younger age (<59 years) and primary EGFR mutation exon 19 (P-values= 0. 028 and 0. 050, respectively). Conclusion: T790M mutations frequency may differ by ethnicity, genetic factors and EGFR primary mutations. Detecting T790M mutations in plasma is considered as an indicator of treatment with third generation EGFR-TKIs.

Cites

No record.

References

No record.

Cite

APA: Copy

MIRTAVOOS MAHYARI, HANIFEH, ABBASI DEZFOULI, AZIZOLLAH, ESFAHANI MONFARED, ZAHRA, KHOSRAVI, ADNAN, SEIFI, SHARAREH, & SHEIKHY, KAMBIZ. (2022). T790M and Acquired Resistance of Epidermal Growth Factor Receptor to Tyrosine Kinase Inhibitors in Patients with Lung Adenocarcinoma. TANAFFOS, 21(3), 376-383. SID. https://sid.ir/paper/1078863/en

Vancouver: Copy

MIRTAVOOS MAHYARI HANIFEH, ABBASI DEZFOULI AZIZOLLAH, ESFAHANI MONFARED ZAHRA, KHOSRAVI ADNAN, SEIFI SHARAREH, SHEIKHY KAMBIZ. T790M and Acquired Resistance of Epidermal Growth Factor Receptor to Tyrosine Kinase Inhibitors in Patients with Lung Adenocarcinoma. TANAFFOS[Internet]. 2022;21(3):376-383. Available from: https://sid.ir/paper/1078863/en

IEEE: Copy

HANIFEH MIRTAVOOS MAHYARI, AZIZOLLAH ABBASI DEZFOULI, ZAHRA ESFAHANI MONFARED, ADNAN KHOSRAVI, SHARAREH SEIFI, and KAMBIZ SHEIKHY, “T790M and Acquired Resistance of Epidermal Growth Factor Receptor to Tyrosine Kinase Inhibitors in Patients with Lung Adenocarcinoma,” TANAFFOS, vol. 21, no. 3, pp. 376–383, 2022, [Online]. Available: https://sid.ir/paper/1078863/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops