Toxicity of Carbon-Based Nanomaterials in the Human Lung: A Comparative In-Vitro Study

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NASIRZADEH NAFISEH; MOHAMMADIAN YOUSEF; RASOULZADEH YAHYA; REZAZADEH AZARI MANSOUR; KHODAGHOLI FARIBA

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Journal: TANAFFOS Year:2022 | Volume:21 | Issue:3 Page(s): 391-400

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Title

Toxicity of Carbon-Based Nanomaterials in the Human Lung: A Comparative In-Vitro Study

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Keywords

Graphite nanoparticles

Graphene nanoparticles

Multiwalled carbon nanotubes

Cytotoxicity

Abstract

Background: Carbon-based nanomaterials (CBNs) are the key elements in nanotechnology. The main challenge presented by CBNs is their relationship with the toxicity exposed in the biological systems, because of the incomplete information on their toxicity. This study is aimed to compare the Cytotoxicity of Graphite nanoparticles (GRNPs), Graphene nanoparticles (GNPs), and Multiwalled carbon nanotubes (MWCNTs) in A549 cells. Materials and Methods: The physicochemical properties of nanomaterials were determined by instrumental techniques. CBNs were dispersed by the nongenotoxic standard procedure. After the cells were cultured, they were exposed to different concentrations of CBNs. Cellular viability was determined by the MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) method. Moreover, toxicological indicators were obtained using linear probit regression. Results: The degree of Cytotoxicity of CBNs in A549 cells was related to the time and, particularly, dose. At the concentrations of lower than 300 μ, g/mL, GNPs had stronger toxicity than MWCNTs, but the cytotoxic effects were reversed with the increase of the concentrations. The no-observed-adverseeffect concentration (NOAEC) of GRNPs, GNPs, and MWCNTs was 1. 76, 0. 06, and 0. 65 μ, g/mL, respectively. Conclusion: The results indicated that CBNs were toxic and GNPs had stronger toxicity than the others. The experimental results can be useful in increasing the knowledge about the toxicity and health risk management of CBNs.

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APA: Copy

NASIRZADEH, NAFISEH, MOHAMMADIAN, YOUSEF, RASOULZADEH, YAHYA, REZAZADEH AZARI, MANSOUR, & KHODAGHOLI, FARIBA. (2022). Toxicity of Carbon-Based Nanomaterials in the Human Lung: A Comparative In-Vitro Study. TANAFFOS, 21(3), 391-400. SID. https://sid.ir/paper/1078870/en

Vancouver: Copy

NASIRZADEH NAFISEH, MOHAMMADIAN YOUSEF, RASOULZADEH YAHYA, REZAZADEH AZARI MANSOUR, KHODAGHOLI FARIBA. Toxicity of Carbon-Based Nanomaterials in the Human Lung: A Comparative In-Vitro Study. TANAFFOS[Internet]. 2022;21(3):391-400. Available from: https://sid.ir/paper/1078870/en

IEEE: Copy

NAFISEH NASIRZADEH, YOUSEF MOHAMMADIAN, YAHYA RASOULZADEH, MANSOUR REZAZADEH AZARI, and FARIBA KHODAGHOLI, “Toxicity of Carbon-Based Nanomaterials in the Human Lung: A Comparative In-Vitro Study,” TANAFFOS, vol. 21, no. 3, pp. 391–400, 2022, [Online]. Available: https://sid.ir/paper/1078870/en

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