Effect of Cigarette versus Electronic Cigarette on the Expression of TERT, FGFR3, PTEN, P53, and VEGF in Rat Bladder

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Afsari Rouhollah; MASHHADI RAHIL; Zareian Baghdadabad Leila; MIRZAEI AKRAM; Zahmatkesh Parisa; Mesbah Gholamreza; KESHAVARZ PAKSERESHT BEHTA; KHAJAVI ALIREZA; Khoshchehreh Mahdi; NOORI MARYAM; RAHIMNIA RAMIN

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Journal: Translational Research in Urology Year:2023 | Volume:5 | Issue:1 Page(s): 51-58

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Title

Effect of Cigarette versus Electronic Cigarette on the Expression of TERT, FGFR3, PTEN, P53, and VEGF in Rat Bladder

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Keywords

Bladder Cancer

E-cigarettes

Rat

Gene Expression

Abstract

Introduction: This investigation aims to assess and compare the effect of cigarettes and E-cigarettes on the expression of TERT, FGFR3, PTEN, P53, and VEGF in Rat bladder. Methods: 60 Wistar Rats were classified into three groups (10): Group A (Control), Group B: case (cigarette smoke), and Group C: case (E-cigarette smoke). The Rats were exposed to cigarettes or E-cigarettes for 10 minutes. These 10 minutes were performed three times a day, and in total, the samples were exposed to cigarettes or E-cigarettes for 40 minutes a day with 1 hour rest for 16 weeks. Results: Histopathological findings showed cigarette-induced hyperplasia and e-cigaretteinduced hyperemia and infiltRation of inflammatory cells. The expression of FGFR3, TERT, and VEGF genes significantly increased and the expression of the PTEN gene significantly decreased in both cigarette and e-cigarette groups in both male and female Rats compared to the control group but these changes were not significant between the two groups. The expression of P53 decreased in both groups, but the female Rat in the e-cigarette significantly increased. Conclusions: We found that both groups changed the expression of genes involved in the development of BC, but no differences were found two groups. Therefore, the e-cigarette is not an excellent alternative to cigarettes.

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APA: Copy

Afsari, Rouhollah, MASHHADI, RAHIL, Zareian Baghdadabad, Leila, MIRZAEI, AKRAM, Zahmatkesh, Parisa, Mesbah, Gholamreza, KESHAVARZ PAKSERESHT, BEHTA, KHAJAVI, ALIREZA, Khoshchehreh, Mahdi, NOORI, MARYAM, & RAHIMNIA, RAMIN. (2023). Effect of Cigarette versus Electronic Cigarette on the Expression of TERT, FGFR3, PTEN, P53, and VEGF in Rat Bladder. TRANSLATIONAL RESEARCH IN UROLOGY, 5(1), 51-58. SID. https://sid.ir/paper/1079196/en

Vancouver: Copy

Afsari Rouhollah, MASHHADI RAHIL, Zareian Baghdadabad Leila, MIRZAEI AKRAM, Zahmatkesh Parisa, Mesbah Gholamreza, KESHAVARZ PAKSERESHT BEHTA, KHAJAVI ALIREZA, Khoshchehreh Mahdi, NOORI MARYAM, RAHIMNIA RAMIN. Effect of Cigarette versus Electronic Cigarette on the Expression of TERT, FGFR3, PTEN, P53, and VEGF in Rat Bladder. TRANSLATIONAL RESEARCH IN UROLOGY[Internet]. 2023;5(1):51-58. Available from: https://sid.ir/paper/1079196/en

IEEE: Copy

Rouhollah Afsari, RAHIL MASHHADI, Leila Zareian Baghdadabad, AKRAM MIRZAEI, Parisa Zahmatkesh, Gholamreza Mesbah, BEHTA KESHAVARZ PAKSERESHT, ALIREZA KHAJAVI, Mahdi Khoshchehreh, MARYAM NOORI, and RAMIN RAHIMNIA, “Effect of Cigarette versus Electronic Cigarette on the Expression of TERT, FGFR3, PTEN, P53, and VEGF in Rat Bladder,” TRANSLATIONAL RESEARCH IN UROLOGY, vol. 5, no. 1, pp. 51–58, 2023, [Online]. Available: https://sid.ir/paper/1079196/en

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