The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice

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HASHEMI FIROUZI NASRIN; SHAHIDI SIAMAK; AFSHAR SIMIN; HABIBI PARISA; RAMEZANI MAHDI

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Journal Paper

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Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2023 | Volume:28 | Issue:2 (125) Page(s): 40-50

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Title

The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice

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Keywords

5-HT2A receptor

Morphine

Withdrawal syndrome

Mice

Abstract

Background and Aim: Serotonergic system has a role in Morphine dependence and withdrawal symptoms via its receptors. On the other hand, the effect of 5-HT2A receptor on withdrawal symptoms has not been evaluated completely. The aim of this study was to investigate the effect of 5-HT2A receptor stimulation on Morphine withdrawal symptoms in male Mice. Materials and Methods: This experimental study included twenty eight male NMRI Mice (20-25g). Morphine dependency was induced in a five-day schedule by 6, 16, 26, 36, 46, 56 and 66 mg/kg doses respectively. On the fifth day, 2 hours after a single dose of Morphine, naloxone was injected (3 mg/kg) and the scores (from 0 to 3) of withdrawal symptoms including number of jumps, teeth chattering, writing, head shakes, limbs shakes, and percentage of body weight loss were recorded for 30min. The treatment group received different doses of TCB-2 (03, and 2. 5mg/kg,Intraperitoneally). Results: Withdrawal symptoms in the Morphine-dependent Mice were significantly more frequent than those in the control Mice. Different doses of TCB-2 significantly increased some of the Morphine withdrawal symptoms in the experimental groups. Conclusion: The present study indicated that stimulation of 5-HT2A receptor via its agonist exacerbated the Morphine withdrawal symptoms. Further studies are recommended to better understand the role of the 5-HT2A receptor in Morphine dependence and withdrawal.

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APA: Copy

HASHEMI FIROUZI, NASRIN, SHAHIDI, SIAMAK, AFSHAR, SIMIN, HABIBI, PARISA, & RAMEZANI, MAHDI. (2023). The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 28(2 (125) ), 40-50. SID. https://sid.ir/paper/1083910/en

Vancouver: Copy

HASHEMI FIROUZI NASRIN, SHAHIDI SIAMAK, AFSHAR SIMIN, HABIBI PARISA, RAMEZANI MAHDI. The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;28(2 (125) ):40-50. Available from: https://sid.ir/paper/1083910/en

IEEE: Copy

NASRIN HASHEMI FIROUZI, SIAMAK SHAHIDI, SIMIN AFSHAR, PARISA HABIBI, and MAHDI RAMEZANI, “The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 2 (125) , pp. 40–50, 2023, [Online]. Available: https://sid.ir/paper/1083910/en

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