Effect of Salix Alba Leaves Hydro-Alcoholic Extract on PTZInduced Seizure in Male Mice

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Khalighi Sigaroudi Fakhri; ROSTAMPOUR MOHAMMAD; SOLTANI TEHRANI BAHRAM

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Journal Paper

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Journal: Journal of Ilam University of Medical Sciences Year:2023 | Volume:30 | Issue:5 Page(s): 32-39

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Information Journal Paper

Title

Effect of Salix Alba Leaves Hydro-Alcoholic Extract on PTZInduced Seizure in Male Mice

Author(s)

Khalighi Sigaroudi Fakhri | ROSTAMPOUR MOHAMMAD | SOLTANI TEHRANI BAHRAM | Issue Writer Certificate

Keywords

Mice

Pentylenetetrazol

Salix Alba leaves

Seizure

Abstract

Introduction: Regarding the chronic nature of epilepsy and resistance to chemical drugs, herbal medicine has received remarkable interest. This study investiagted the anticonvulsant effects of hydro-alcoholic extract of Salix Alba leaves on PTZ-induced Seizure in male Mice. Material & Methods: In total, 56 albino male Mice weighing 20-25 g were divided randomly into seven groups (8 animals per group) including negative (saline), positive (Phenobarbital) control, and five groups which received different doses of hydro-alcoholic extract of Salix Alba leaves. After 45 min, all groups received the convulsant pentylene tetrazole, and the onset time of myoclonic, tonic-clonic Seizures, and the 24-hour mortality rate were measured. (Ethic code: IR. GUMS. REC. 1394. 566) Findings: The extract significantly delayed the onset of myoclonic and tonic-clonic Seizures at a dose of 100 mg/kg (P<0. 01) and for other doses (P<0. 001), compared to the control group. Moreover, the extract decreased the 24-h death. This was significant at 1000 mg/kg (P<0. 001), as well as 300, 500, and 800 mg/kg (P<0. 05), compared to the control group. Discussion & Conclusion: It seems that the hydro-alcoholic extract of Salix Alba leaves have a significant diminishing effect on PTZ-induced Seizures in male Mice which is due to its anti-inflammatory and antioxidant effects.

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APA: Copy

Khalighi Sigaroudi, Fakhri, ROSTAMPOUR, MOHAMMAD, & SOLTANI TEHRANI, BAHRAM. (2023). Effect of Salix Alba Leaves Hydro-Alcoholic Extract on PTZInduced Seizure in Male Mice. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 30(5 ), 32-39. SID. https://sid.ir/paper/1084494/en

Vancouver: Copy

Khalighi Sigaroudi Fakhri, ROSTAMPOUR MOHAMMAD, SOLTANI TEHRANI BAHRAM. Effect of Salix Alba Leaves Hydro-Alcoholic Extract on PTZInduced Seizure in Male Mice. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2023;30(5 ):32-39. Available from: https://sid.ir/paper/1084494/en

IEEE: Copy

Fakhri Khalighi Sigaroudi, MOHAMMAD ROSTAMPOUR, and BAHRAM SOLTANI TEHRANI, “Effect of Salix Alba Leaves Hydro-Alcoholic Extract on PTZInduced Seizure in Male Mice,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 5 , pp. 32–39, 2023, [Online]. Available: https://sid.ir/paper/1084494/en

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