Evaluation of the Effect of Topical Pistachio Hull Hydroalcoholic Extract Ointment on Wound Healing in Rat: A Histologic and Planimetric Study

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POURJABALI MASOUMEH; ZAREI LEILA; Ezzati Sarai Vahid

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Journal Paper

Paper Information

Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2022 | Volume:27 | Issue:3 (120) Page(s): 12-22

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Information Journal Paper

Title

Evaluation of the Effect of Topical Pistachio Hull Hydroalcoholic Extract Ointment on Wound Healing in Rat: A Histologic and Planimetric Study

Author(s)

POURJABALI MASOUMEH | ZAREI LEILA | Ezzati Sarai Vahid | Issue Writer Certificate

Keywords

Ointments

Medicinal plants

Plant extracts

Staining

Abstract

Background and Aim: Pistachio nut and hull have anti-inflammatory, antimicrobial and antioxidant effects. The aim of this study was to investigate the effects of pistachio hull hydroalcoholic extract ointment on wound healing process. Materials and methods: For wound planimetric assessment, 20 healthy rats were randomly divided into 5 groups of 4, including control group (open wound without any intervention and treatment), positive control group (open wound with basic ointment without extract), and the 3 other groups receiving 1%, 2% and 4% Ointments respectively. On the 7th and 14th days, biopsies from wound tissues were taken and after Mason Trichrome Staining we evaluated collagen. H&E Staining was done for histopathological assessments. Results: The results showed that wound treatment with pistachio hull ointment in the experimental groups showed a significant increase (P<0. 05) in the percentage of wound healing rate. Also, there was a significant difference in the thickness of skin and collagen diameter, and reduction of edema between experimental and control groups (P<0. 05). Also we found significant decrease in inflammatory cell count on the 14th day in the groups treated with pistachio hull extract compared to those in the control group (P<0. 05), which was indicative of accelerated wound healing in the experimental groups. Conclusion: According to the results of this study, pistachio hull hydroalcoholic extract ointment potentially possesses healing effects on the wound created in the skin of the rat.

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APA: Copy

POURJABALI, MASOUMEH, ZAREI, LEILA, & Ezzati Sarai, Vahid. (2022). Evaluation of the Effect of Topical Pistachio Hull Hydroalcoholic Extract Ointment on Wound Healing in Rat: A Histologic and Planimetric Study. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 27(3 (120) ), 12-22. SID. https://sid.ir/paper/1084851/en

Vancouver: Copy

POURJABALI MASOUMEH, ZAREI LEILA, Ezzati Sarai Vahid. Evaluation of the Effect of Topical Pistachio Hull Hydroalcoholic Extract Ointment on Wound Healing in Rat: A Histologic and Planimetric Study. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;27(3 (120) ):12-22. Available from: https://sid.ir/paper/1084851/en

IEEE: Copy

MASOUMEH POURJABALI, LEILA ZAREI, and Vahid Ezzati Sarai, “Evaluation of the Effect of Topical Pistachio Hull Hydroalcoholic Extract Ointment on Wound Healing in Rat: A Histologic and Planimetric Study,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 3 (120) , pp. 12–22, 2022, [Online]. Available: https://sid.ir/paper/1084851/en

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