THE MODIFIED AGNOR STAINING IN DIAGNOSIS OF BENIGN AND MALIGNANT SALIVARY GLAND TUMORS

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ANDISHEH TADBIR A.; ASHRAF M.J.; KETABI M.A.

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Journal: JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES) Year:2010 | Volume:10 | Issue:4 (25) Page(s): 322-329

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Title

THE MODIFIED AGNOR STAINING IN DIAGNOSIS OF BENIGN AND MALIGNANT SALIVARY GLAND TUMORS

Author(s)

ANDISHEH TADBIR A. | ASHRAF M.J. | KETABI M.A. | Issue Writer Certificate

Keywords

MODIFIED AGNORQ2

PLEOMORPHIC ADENOMAQ2

WARTHIN TUMORQ2

ADENOID CYSTIC CARCINOMAQ2

MUCOEPIDERMOID CARCINOMAQ2

Abstract

Statement of problem: Salivary gland neoplasms show varied histological and biological characteristics, and there may be difficulty in differentiating between low grade malignancies and benign tumors of the salivary glands.Purpose: The aim of this study was to investigate the diagnostic value of MODIFIED AGNOR technique in distinguishing between benign and malignant salivary gland tumors.Materials and Method: In this cross-sectional study, 40 benign salivary gland tumors (34 PLEOMORPHIC ADENOMA, 6 WARTHIN TUMOR), 40 malignant neoplasms (26 ADENOID CYSTIC CARCINOMA, 14 MUCOEPIDERMOID CARCINOMA) and 10 chronic sialadenitis were stained with MODIFIED AGNOR technique. AgNOR counts, variation in size and dispersion of AgNOR dots in the cells were graded and compared in benign and malignant tumors. The data were statistically analyzed by ANOVA, Tukey, t-test and Kruskal-Wallis tests.Results: The mean AgNOR counts for the benign neoplasms (1.29±0.13) were less than those for the malignant neoplasms (2.87±0.25). Variation in AgNOR size and dispersion was of a higher grade in malignancy when compared with benign neoplasms (p<0.05).Conclusion: Our results suggest that MODIFIED AGNOR staining is useful for distinguishing benign from malignant tumors, but variation in AgNOR size and dispersion in addition to the count should also be considered.

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APA: Copy

ANDISHEH TADBIR, A., ASHRAF, M.J., & KETABI, M.A.. (2010). THE MODIFIED AGNOR STAINING IN DIAGNOSIS OF BENIGN AND MALIGNANT SALIVARY GLAND TUMORS. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 10(4 (25)), 322-329. SID. https://sid.ir/paper/108487/en

Vancouver: Copy

ANDISHEH TADBIR A., ASHRAF M.J., KETABI M.A.. THE MODIFIED AGNOR STAINING IN DIAGNOSIS OF BENIGN AND MALIGNANT SALIVARY GLAND TUMORS. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2010;10(4 (25)):322-329. Available from: https://sid.ir/paper/108487/en

IEEE: Copy

A. ANDISHEH TADBIR, M.J. ASHRAF, and M.A. KETABI, “THE MODIFIED AGNOR STAINING IN DIAGNOSIS OF BENIGN AND MALIGNANT SALIVARY GLAND TUMORS,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 10, no. 4 (25), pp. 322–329, 2010, [Online]. Available: https://sid.ir/paper/108487/en

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