مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

9
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

3
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effects of oleanolic acid administration on renal NF-κ, B/IL-18/ IL-6 and YKL-40/KIM-1 pathways in experimental diabetic rats

Pages

  1188-1193

Abstract

 Objective(s): Neuropathy, retinopathy, and nephropathy, known as the triopathy of Diabetes, are the consequences of microvascular complications of Diabetes. The present study aimed to investigate the potential protective effects of Oleanolic acid (OA) administration against diabetic nephropathy considering biochemical and histopathological parameters. Materials and Methods: The rats with fasting blood glucose levels of 200 mg/dl and above were considered diabetic after induction of Diabetes via injecting STZ. The other half of the rats were not injected with STZ (healthy rats). Both healthy and diabetic rats were then divided randomly into two subgroups to be administered with either OA (5 mg/kg) with 1 ml tap water by oral gavage or 1 ml tap water in the same route for 21 days. Serum urea-N, Ca, P, and Mg as well as renal tissue MDA, SOD, NF-κ, B, IL-6, IL-18, AMPK, YKL-40, and KIM-1 levels were measured. Results: OA administration partially decreased levels of serum urea-N and P, as well as levels of renal tissue MDA and inflammation markers (NF-κ, B, IL-6, IL-18, YKL-40, and KIM-1) in the diabetic rats. It also partially increased serum Ca and renal tissue AMPK levels in diabetic rats. These positive effects were also seen in renal tissue histopathology. Conclusion: OA treatment partially alleviated renal damage inflammatory and oxidative profiles in diabetic rats.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Iskender, Hatice, Dokumacioglu, Eda, Hayirli, Armagan, Terim Kapakin, Kubra Asena, Bolat, Ismail, & Manavoglu Kirman, Esra. (2023). Effects of oleanolic acid administration on renal NF-κ, B/IL-18/ IL-6 and YKL-40/KIM-1 pathways in experimental diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(10), 1188-1193. SID. https://sid.ir/paper/1084881/en

    Vancouver: Copy

    Iskender Hatice, Dokumacioglu Eda, Hayirli Armagan, Terim Kapakin Kubra Asena, Bolat Ismail, Manavoglu Kirman Esra. Effects of oleanolic acid administration on renal NF-κ, B/IL-18/ IL-6 and YKL-40/KIM-1 pathways in experimental diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(10):1188-1193. Available from: https://sid.ir/paper/1084881/en

    IEEE: Copy

    Hatice Iskender, Eda Dokumacioglu, Armagan Hayirli, Kubra Asena Terim Kapakin, Ismail Bolat, and Esra Manavoglu Kirman, “Effects of oleanolic acid administration on renal NF-κ, B/IL-18/ IL-6 and YKL-40/KIM-1 pathways in experimental diabetic rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 10, pp. 1188–1193, 2023, [Online]. Available: https://sid.ir/paper/1084881/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button